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Artificial Intelligence Application in COVID-19 Diagnosis and Prediction

16 Pages Posted: 27 Feb 2020

See all articles by Minfei Peng

Minfei Peng

Wenzhou Medical University - Affiliated Taizhou Hospital

Jie Yang

University of Macau - Department of Computer and Information Science

Qingxin Shi

Wenzhou Medical University - Affiliated Taizhou Hospital

Lingjun Ying

Wenzhou Medical University - Affiliated Taizhou Hospital

Hongguo Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Guangjun Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Xianhong Ding

Wenzhou Medical University - Affiliated Taizhou Hospital

Zebao He

Wenzhou Medical University - Affiliated Taizhou Hospital

Jiajia Qin

Wenzhou Medical University - Affiliated Taizhou Hospital

Jing Wang

Wenzhou Medical University - Affiliated Taizhou Hospital

Haixi Yan

Wenzhou Medical University - Affiliated Taizhou Hospital

Xiaojie Bi

Wenzhou Medical University - Affiliated Taizhou Hospital

Bo Shen

Wenzhou Medical University - Affiliated Taizhou Hospital

Donglian Wang

Wenzhou Medical University - Affiliated Taizhou Hospital

Lifei Luo

Wenzhou Medical University - Affiliated Taizhou Hospital

Haihong Zhao

Wenzhou Medical University - Affiliated Taizhou Hospital

Chao Zhang

Wenzhou Medical University - Affiliated Taizhou Hospital

Zongmei Lin

Wenzhou Medical University - Affiliated Taizhou Hospital

Luxiao Hong

Wenzhou Medical University - Affiliated Taizhou Hospital

Lingping Zhang

Wenzhou Medical University - Affiliated Taizhou Hospital

Jiaqin Xu

Wenzhou Medical University - Affiliated Taizhou Hospital

Ruyue Lu

Wenzhou Medical University - Affiliated Taizhou Hospital

Bingjie Hu

Wenzhou Medical University - Affiliated Taizhou Hospital

Chenliang Hong

Wenzhou Medical University - Affiliated Taizhou Hospital

Xiangyu Xu

Wenzhou Medical University - Affiliated Taizhou Hospital

Jiaxi Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Chong Liu

Wenzhou Medical University - Affiliated Taizhou Hospital

Yijun Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Yunda Cai

Wenzhou Medical University - Affiliated Taizhou Hospital

Qiqi Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Junyu Jiang

Wenzhou Medical University - Affiliated Taizhou Hospital

Lihong Yang

Wenzhou Medical University - Affiliated Taizhou Hospital

Sufei Yu

Wenzhou Medical University - Affiliated Taizhou Hospital

Xiaomai Wu

Wenzhou Medical University - Affiliated Taizhou Hospital

Zhencang Zheng

Wenzhou Medical University - Affiliated Taizhou Hospital

Simon Fong

University of Macau - Department of Computer and Information Science

Qi Zhao

University of Macau - Cancer Centre

Shiyong Chen

Wenzhou Medical University - Department of Clinical Laboratory

Shigao Huang

University of Macau - Cancer Centre

Jun Li

Wenzhou Medical University - Department of Clinical Laboratory

More...

Abstract

Background: On December 8, 2019, the first new coronavirus case was discovered in Wuhan, China, and an intensive outbreak incepted in the next month (about January 20). Virologicalists and epidemiologists predict that it will reach a peak in about 90 days and fade away till the end in about 4 months (Early April), the entire epidemic will terminate in early May. The daily rise in confirmed cases and the increase in the number of outbreak communities on the epidemic map always hit the nerves of panic. On January 31, 2020, the World Health Organization (WHO) declared China ’s new coronavirus epidemic an “public health emergency of international concern” (PHEIC). At this time, citizens from multiple nations including China express their grave concerns on the diagnosis, prediction and heal of the virus contagion.

Objective: This research will analyze the COVID-19 general diagnosis index with artifical intelligence (AI) to improve the diagnosis accuracy for clinical purpose.

Methods: We included 32 cases of COVID-19 diagnosed, and 85 undiagnosis patients in Taizhou Public Hygiene in Taizhou Hospital, of Zhejiang province, between January 17, 2020 and February 1, 2020, and the positive confirmed patients were diagnosized by real-time RT-PCR. At the same time, 85 patients with negative nucleic acid of COVID-19 were collected during the same period, and the results were followed up to February 2, 2020. Among radiological characteristics and laboratory data (the first result of the Group) for analysis. We used four types of AI techonlogy to screen important index regarding COVID-19 diagnosis. several classical and state-of-the-art attribute reduction and feature selection methods, sparse rescaled linear square regression (SRLSR), evolutionary non-dominated radial slots based algorithm, attribute reduction with multi-objective decomposition-ensemble optimizer (ARMED), Gradient boosted feature selection (GFS), recursive feature elimination (RFE), were applied to deal with this problem.

Results: We employed four types of AI technology to screen all patients, achieve 18 indexes associated with significant COVID-19 diagnosis and the most important attribute is WBC, Eosinophil count, Eosinophil rate, 2019 novel coronavirus RNA (2019n-CoV) and Amyloid-A in laboratory, also matched with 2019 China virus diagnosis clinical guide.

Conclusion: We developed a novel and accurate method to quickly achieve COVID-19 diagnosis association indexes to improve confirmed diagnosis rate for clinical use.

Funding Statement: This work is funded by the Science and Technology Development Fund of Macau (FDCT/131/2016/A3, FDCT/0015/2018/A1, FDCT/126/2014/A3) and Start-up Research Grant (SRG2016-00082-FHS), the Multi-Year Research Grant (MYRG2019-00069-FHS, MYRG2016-00069-FST), the intramural research program of Faculty of Health Sciences, University of Macau, Guangzhou Science and Technology Innovation and Development of Special Funds, Grant no. EF003/FST-FSJ/2019/GSTIC, and Grant no. EF004/FST-FSJ/2019/GSTI, project of "New coronavirus infection and prevention" Emergency Scientific Research of Chongqing Education Commission of China, and the project of science and technology research program of Chongqing Education Commission of China(KJQN201903601).

Declaration of Interests: None.

Ethics Approval Statement: This study was approved by the Institutional Medical Ethics Review Board of Taizhou Hospital of Zhejiang Province.

Keywords: Artifical intelligence, 2019 coronavirus, diagnosis, prediction

Suggested Citation

Peng, Minfei and Yang, Jie and Shi, Qingxin and Ying, Lingjun and Zhu, Hongguo and Zhu, Guangjun and Ding, Xianhong and He, Zebao and Qin, Jiajia and Wang, Jing and Yan, Haixi and Bi, Xiaojie and Shen, Bo and Wang, Donglian and Luo, Lifei and Zhao, Haihong and Zhang, Chao and Lin, Zongmei and Hong, Luxiao and Zhang, Lingping and Xu, Jiaqin and Lu, Ruyue and Hu, Bingjie and Hong, Chenliang and Xu, Xiangyu and Chen, Jiaxi and Liu, Chong and Chen, Yijun and Cai, Yunda and Zhu, Qiqi and Jiang, Junyu and Yang, Lihong and Yu, Sufei and Wu, Xiaomai and Zheng, Zhencang and Fong, Simon and Zhao, Qi and Chen, Shiyong and Huang, Shigao and Li, Jun, Artificial Intelligence Application in COVID-19 Diagnosis and Prediction (2/17/2020). Available at SSRN: https://ssrn.com/abstract=3541119 or http://dx.doi.org/10.2139/ssrn.3541119

Minfei Peng (Contact Author)

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jie Yang

University of Macau - Department of Computer and Information Science

Taipa
Macau

Qingxin Shi

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Lingjun Ying

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Hongguo Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Guangjun Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Xianhong Ding

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Zebao He

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jiajia Qin

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jing Wang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Haixi Yan

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Xiaojie Bi

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Bo Shen

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Donglian Wang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Lifei Luo

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Haihong Zhao

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Chao Zhang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Zongmei Lin

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Luxiao Hong

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Lingping Zhang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jiaqin Xu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Ruyue Lu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Bingjie Hu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Chenliang Hong

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Xiangyu Xu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jiaxi Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Chong Liu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Yijun Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Yunda Cai

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Qiqi Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Junyu Jiang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Lihong Yang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Sufei Yu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Xiaomai Wu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Zhencang Zheng

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Simon Fong

University of Macau - Department of Computer and Information Science

Taipa
Macau

Qi Zhao

University of Macau - Cancer Centre

China

Shiyong Chen

Wenzhou Medical University - Department of Clinical Laboratory ( email )

China

Shigao Huang

University of Macau - Cancer Centre ( email )

China

Jun Li

Wenzhou Medical University - Department of Clinical Laboratory ( email )

China

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