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Clinical Efficacy of Arbidol in Patients with 2019 Novel Coronavirus-Infected Pneumonia: A Retrospective Cohort Study

28 Pages Posted: 25 Feb 2020

See all articles by Kaijin Xu

Kaijin Xu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Yanfei Chen

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Jing Yuan

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Ping Yi

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Cheng Ding

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Wenrui Wu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Yongtao Li

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Qin Ni

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Rongrong Zhou

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Xiaohe Li

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Min Xu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Ying Zhang

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Hong Zhao

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Xuan Zhang

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Liang Yu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Junwei Su

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Guanjing Lang

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Jun Liu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Xiaoxin Wu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Yongzheng Guo

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Jingjing Tao

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Ding Shi

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Ling Yu

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Qing Cao

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Bing Ruan

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Lei Liu

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Wang Zhaoqin

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Yan Xu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Liu Yingxia

Southern University of Science and Technology - State Key Discipline of Infectious Disease

Jifang Sheng

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Lanjuan Li

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

More...

Abstract

Background: The urgency of the 2019 novel coronavirus outbreak has led to demand of effective antiviral agents. Preliminary experiment indicated that Arbidol concentrations might inhibit the replication of coronavirus in vitro. However, there was limited data about the clinical efficacy of Arbidol in 2019 novel coronavirus-infected pneumonia (NCP).

Methods: We did a retrospective cohort study of NCP patients who received empiric al antiviral regimens with or without Arbidol. A total of 111 patients from two clinical centers in China were enrolled.

Findings: Among these patients, 49 were assigned to the empirical treatment with Arbidol group ( group A+ER ) and 62 were assigned to the empirical regimens group (group ER). During the observation period, we found 59.2% patients in group A+ER had virologic conversion at least once, which was significantly higher than 40.3% in group ER (P=0.048). The need for high flow nasal catheter (HFNC) oxygen therapy in hospitalization was obviously reduced in group A+ER than in group ER (P=0.002). About 55.1% patients in group A+ER had focal absorption on chest CT images, obviously higher than 32.2% in group ER (P=0.016). The beneficial effect of Arbidol was more apparent in patients with mild illness severity at admission. The median conversion time of the stable virologic conversion of mild patients in group A+ER can be shortened 2 days than that in group ER (P=0.020). Side effects of the Arbidol were minimal in this study.

Interpretation: Our results suggest that Arbidol could accelerate and enhance the process of viral clearance, improve focal absorption on radiologic images, and reduce the demand for HFNC oxygen therapy in hospitalization. These effects were particularly pronounced in patients with mild illness at admission. The results provide basis for clinical use of Arbidol and supports for further randomized controlled trials in patients with NCP.

Funding Statement: This study was funded by the National Science and Technology Major Project of China (2017ZX10105001); National Human Genetic Resources Sharing Service Platform (Grant No. 2005DKA21300); Sanming Project of Medicine in Shenzhen (No. SZSM201512005).

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: Ethics approval was obtained from the Institutional Review Board of the First Affiliated Hospital, School of Medicine, Zhejiang University and the Shenzhen Third People’s Hospital.

Keywords: retrospective study; antiviral therapy; COVID-19; virus clearance; SARS-CoV-2; treatment response

Suggested Citation

Xu, Kaijin and Chen, Yanfei and Yuan, Jing and Yi, Ping and Ding, Cheng and Wu, Wenrui and Li, Yongtao and Ni, Qin and Zhou, Rongrong and Li, Xiaohe and Xu, Min and Zhang, Ying and Zhao, Hong and Zhang, Xuan and Yu, Liang and Su, Junwei and Lang, Guanjing and Liu, Jun and Wu, Xiaoxin and Guo, Yongzheng and Tao, Jingjing and Shi, Ding and Yu, Ling and Cao, Qing and Ruan, Bing and Liu, Lei and Zhaoqin, Wang and Xu, Yan and Yingxia, Liu and Sheng, Jifang and Li, Lanjuan, Clinical Efficacy of Arbidol in Patients with 2019 Novel Coronavirus-Infected Pneumonia: A Retrospective Cohort Study (2/12/2020). Available at SSRN: https://ssrn.com/abstract=3542148 or http://dx.doi.org/10.2139/ssrn.3542148

Kaijin Xu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Yanfei Chen

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Jing Yuan

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Shenzhen
China

Ping Yi

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Cheng Ding

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Wenrui Wu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Yongtao Li

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Qin Ni

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Rongrong Zhou

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Xiaohe Li

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Min Xu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Ying Zhang

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Shenzhen
China

Hong Zhao

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Xuan Zhang

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Liang Yu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Junwei Su

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Guanjing Lang

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Jun Liu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Xiaoxin Wu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Yongzheng Guo

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Jingjing Tao

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Ding Shi

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Ling Yu

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Shenzhen
China

Qing Cao

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Bing Ruan

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Lei Liu

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Shenzhen
China

Wang Zhaoqin

Southern University of Science and Technology - Diagnosis and Treatment of Infectious Diseases Research Laboratory

Shenzhen
China

Yan Xu

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Liu Yingxia

Southern University of Science and Technology - State Key Discipline of Infectious Disease ( email )

Shenzhen
China

Jifang Sheng

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases ( email )

38 Zheda Road
Hangzhou, Zhejiang 310058
China

Lanjuan Li (Contact Author)

Zhejiang University - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases ( email )

38 Zheda Road
Hangzhou, Zhejiang 310058
China

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