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Epidemiological and Clinical Characteristics of 124 Elderly Outpatients with COVID-19 in Wuhan, China

16 Pages Posted: 28 Feb 2020

See all articles by Yan Lin

Yan Lin

Tongde Hospital of Zhejiang Province - Department of Pharmacy

Chunlian Ji

Tongde Hospital of Zhejiang Province - Intensive Care Unit

Weidong Weng

Tongde Hospital of Zhejiang Province - Infectious Disease Department

Pan Xu

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

Yijuan Hu

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

Weiqing Liang

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

Jinbao Pu

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

Hongjian Zhang

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

More...

Abstract

Background: Since the end of 2019, a pneumonia epidemic with the 2019 novel coronavirus disease (COVID-19; previously known as 2019-nCoV) emerged in Wuhan, China. And the number of infections far exceeds the scope that medical institutions can treat. However, there was not noticed the information of elderly patients with COVID-19 who were not admitted to the hospital in time.

Methods: In this retrospective study, we collected 124 confirmed or suspected elderly outpatients infected with COVID-19 in 30 hospitals from Jan 22 to Feb 11, 2020 in Wuhan. The cases were performed using the latest diagnostic methods and comparative analysis of epidemiological, symptomatic, detection and computed tomographic (CT) data.

Findings: Of the 124 outpatients included 60 males and 64 females, with a median age of 64 years (interquartile range, 57-71 years; range, 50-87 years), and 30 were close contacts of the confirmed patient of COVID-19. The median distance between the patient's residence and the hospital was 5.3 km (interquartile range, 2.1-9.8 km), and the median time illness onset day was 7 days (interquartile range, 5-10 days). Patients had common symptoms of fever and cough, or with respiratory and other systemic symptoms. According to laboratory examination, 82 (66.1%) patients showed lymphopenia and C-reactive protein (CRP) increased in 97 of 99 tested patients. Imaging examination showed 114 (92%) patient of bilateral pneumonia, and 12 (10%) patient had unilateral right pneumonia or bilateral pneumonia. 33 (27%) patient were evaluated by real-time RT-PCR, of these 5 (15%) patients had negative results, and the median time from symptom onset to confirm was 9 days (interquartile range, 7-11 days).

Interpretation: The COVID-19 infection was a mass onset, with a strong concealment that is difficult to detect in the early stages, and early detection can reduce the harm of the disease. Due to traffic control and tight medical resources, the inability to treat in a timely manner will lead to worsening of the disease of elderly patients, and even fatal respiratory diseases.

Funding Statement: This study was funded by the Program of Zhejiang Provincial Department of Science and Technology (LGF20H280003), the Project of Science and Technology of Traditional Chinese Medicine of Zhejiang Province (2020ZX004).

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: The study was approved by the National Health Commission and the institutional board of each participating site. Oral consent was obtained from patients.

Keywords: COVID-19; elderly outpatient; epidemiological; clinical characteristics; Wuhan

Suggested Citation

Lin, Yan and Ji, Chunlian and Weng, Weidong and Xu, Pan and Hu, Yijuan and Liang, Weiqing and Pu, Jinbao and Zhang, Hongjian, Epidemiological and Clinical Characteristics of 124 Elderly Outpatients with COVID-19 in Wuhan, China (2/20/2020). Available at SSRN: https://ssrn.com/abstract=3543596 or http://dx.doi.org/10.2139/ssrn.3543596

Yan Lin

Tongde Hospital of Zhejiang Province - Department of Pharmacy

Hangzhou
China

Chunlian Ji

Tongde Hospital of Zhejiang Province - Intensive Care Unit

Hangzhou
China

Weidong Weng

Tongde Hospital of Zhejiang Province - Infectious Disease Department

Hangzhou
China

Pan Xu

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

Hangzhou, 310007
China

Yijuan Hu

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

Hangzhou, 310007
China

Weiqing Liang

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

Hangzhou, 310007
China

Jinbao Pu

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province

Hangzhou, 310007
China

Hongjian Zhang (Contact Author)

Zhejiang Academy of Traditional Chinese Medicine - Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province ( email )

Hangzhou, 310007
China

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