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Low Serum Cholesterol Level Among Patients with COVID-19 Infection in Wenzhou, China

21 Pages Posted: 2 Mar 2020

See all articles by Xingzhong Hu

Xingzhong Hu

Wenzhou Central Hospital

Dong Chen

Wenzhou Central Hospital

Lianpeng Wu

Wenzhou Central Hospital

Guiqing He

Wenzhou Central Hospital

Wei Ye

Wenzhou Medical University - School of Laboratory Medicine and Life Science

More...

Abstract

Background: A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel coronavirus COVID-19. Meanwhile, as the infection progressed, a large number of cases were also diagnosed in Wenzhou, China. The objective of the study is to describe the clinical laboratory features, especially lipid profile of the patients with COVID-19 infection in Wenzhou.

Methods: All cases were in a designated hospital in Wenzhou, and confirmed by positive virial nucleic acid detection through PCR assay. All clinical laboratory data were from the first test results after their admission. The unpaired t test was used for data analysis.

Findings: The absolute value of white blood cells, neutrophils and lymphocytes were lower than healthy controls ( P <0.05), more significantly, the patients had sharply decreased total cholesterol (TC), HDL-cholesterol and LDL-cholesterol levels ( P <0.001), 3.70±0.09mmol/L, 1.18±0.03 mmol/L and 1.82±0.08 mmol/L respectively, and increased monocyte/HDL-cholesterol ratio (0.37±0.02 vs 0.28±0.01 in healthy control). Among the patients, the primary infection cases showed the lower HDL-cholesterol levels (1.10±0.04 mmol/L) and higher monocyte/HDL-cholesterol ratio (0.43±0.03) than the secondary infection cases by person-to-person transmission ( P <0.05). Compared with the female patients, the male patients had higher levels of monocytes [(0.46±0.02) ×10 9 /L], M/HDL-C ratio (0.44±0.02), and lactate dehydrogenase (LDH, 257.6±12.32 U/l).

Interpretation: Low serum cholesterol level in the patients with COVID-19 in Wenzhou, China. Altered serum cholesterol provide important information, and is meaningful to understand the disease.

Funding Statement: This work is funded by Natural Science Foundation of Zhejiang Province (LQ18H020005).

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: This study was authorized by Ethics Commission of Wenzhou Central Hospital.

Keywords: coronavirus, COVID-19, lipid, cholesterol

Suggested Citation

Hu, Xingzhong and Chen, Dong and Wu, Lianpeng and He, Guiqing and Ye, Wei, Low Serum Cholesterol Level Among Patients with COVID-19 Infection in Wenzhou, China (February 21, 2020). Available at SSRN: https://ssrn.com/abstract=3544826 or http://dx.doi.org/10.2139/ssrn.3544826

Xingzhong Hu

Wenzhou Central Hospital

China

Dong Chen

Wenzhou Central Hospital

China

Lianpeng Wu

Wenzhou Central Hospital

China

Guiqing He

Wenzhou Central Hospital

China

Wei Ye (Contact Author)

Wenzhou Medical University - School of Laboratory Medicine and Life Science ( email )

Wenzhou, 325000
China

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