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Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: A Retrospective Case Series Study

18 Pages Posted: 2 Mar 2020

See all articles by Ling Mao

Ling Mao

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Mengdie Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Shengcai Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Quanwei He

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Jiang Chang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Epidemiology and Biostatistics

Candong Hong

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Yifan Zhou

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

David Wang

St. Joseph's Hospital and Medical Center - Neurovascular Division

Xiaoping Miao

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Epidemiology and Biostatistics

Yu Hu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Institute of Hematology; Huazhong University of Science and Technology (Formerly Tongi Medical University) - Collaborative Innovation Center of Hematology

Yanan Li

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Huijuan Jin

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Bo Hu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

More...

Abstract

Background: The outbreak of coronavirus disease 2019 (COVID-19) from Wuhan China is serious and has the potential to become epidemic unfortunately worldwide. We aimed to describe the neurological manifestations of patients with COVID-19.

Methods: In this retrospective, observational study, we enrolled two hundred fourteen hospitalized patients with laboratory confirmed diagnosis of severe acute respiratory syndrome from coronavirus 2 (SARS-CoV-2) infection in three designated COVID-19 care hospitals of the Union Hospitals of Huazhong University of Science and Technology in Wuhan, China. Data were collected from 16 January 2020 to 19 February 2020. Neurological symptoms fall into three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system (PNS) symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscle injury. Data of all neurological symptoms were checked by two trained neurologists.

Findings: Of 214 patients studied, 88 (41.1%) were severe and 126 (58.9%) were non-severe patients. Compared with non-severe patients, severe patients were older (58.7 ± 15.0 years vs 48.9 ± 14.7 years), had more underlying disorders (42 [47.7%] vs 41 [32.5%]), especially hypertension (32 [36.4%] vs 19 [15.1%]), and showed less typical symptoms such as fever (40 [45.5%] vs 92 [73%]) and cough (30 [34.1%] vs 77 [61.1%]). Seventy-eight (36.4%) patients had neurologic manifestations. More severe patients were likely to have neurologic symptoms (40 [45.5%] vs 38 [30.2%]), such as acute cerebrovascular diseases (5 [5.7%] vs 1 [0.8%]), impaired consciousness (13 [14.8%] vs 3 [2.4%]) and skeletal muscle injury (17 [19.3%] vs 6 [4.8%]).

Interpretation: Compared with non-severe patients with COVID-19, severe patients commonly had neurologic symptoms manifested as acute cerebrovascular diseases, impaired consciousness and skeletal muscle injury.

Funding Statement: The authors stated: "None."

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: The study was approved by the Ethics Committee of Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Verbal consent was obtained from patients before the enrollment.

Keywords: Coronavirus; COVID-19; Neurological Manifestations; retrospective case series study

Suggested Citation

Mao, Ling and Wang, Mengdie and Chen, Shengcai and He, Quanwei and Chang, Jiang and Hong, Candong and Zhou, Yifan and Wang, David and Miao, Xiaoping and Hu, Yu and Li, Yanan and Jin, Huijuan and Hu, Bo, Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: A Retrospective Case Series Study (February 24, 2020). Available at SSRN: https://ssrn.com/abstract=3544840 or http://dx.doi.org/10.2139/ssrn.3544840

Ling Mao (Contact Author)

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Wuhan, 430022
China

Mengdie Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Wuhan, 430022
China

Shengcai Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Wuhan, 430022
China

Quanwei He

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Wuhan, 430022
China

Jiang Chang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Epidemiology and Biostatistics

China

Candong Hong

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Wuhan, 430022
China

Yifan Zhou

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology

Wuhan, 430022
China

David Wang

St. Joseph's Hospital and Medical Center - Neurovascular Division

China

Xiaoping Miao

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Epidemiology and Biostatistics ( email )

China

Yu Hu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Institute of Hematology ( email )

Wuhan
China

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Collaborative Innovation Center of Hematology ( email )

Wuhan
China

Yanan Li

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology ( email )

Wuhan, 430022
China

Huijuan Jin

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology ( email )

Wuhan, 430022
China

Bo Hu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Neurology ( email )

Wuhan, 430022
China

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