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Clinical Characteristics of COVID-19 in Children Compared with Adults Outside of Hubei Province in China

23 Pages Posted: 5 Mar 2020

See all articles by Wenjun Du

Wenjun Du

Shandong University - Jinan Infectious Diseases Hospital

Jinhong Yu

Shandong University - Jinan Infectious Diseases Hospital

Hui Wang

Rizhao People's Hospital - Department of Infectious Diseases

Xiaoguo Zhang

Shandong University - Jinan Infectious Diseases Hospital

Shouwei Zhang

Rizhao People's Hospital - Department of Infectious Diseases

Qiang Li

Shandong University - Jinan Infectious Diseases Hospital

Zhongfa Zhang

Shandong University - Jinan Infectious Diseases Hospital

More...

Abstract

Aims &Background: The COVID-19 outbreak spread in China and is a threat to the world. We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment.

Methods: Retrospectively, two research centers’ case series of 67 consecutive hospitalized cases including 14 children cases with COVID-19 between 23 Jan 2020 to 15 Feb 2020 from Jinan and Rizhao were enrolled in this study. Epidemiological, clinical, laboratory, and radiological characteristics of children and adults were analyzed and compared.

Results: Most cases in children were mild(21.4%) and conventional cases (78.6%), with mild clinical signs and symptoms, and all cases were of family clusters. Fever (35.7%) and dry cough (21.4%) were described as clinical manifestations in children cases. Dry cough and phlegm were not the most common symptoms in children compared with adults (p=0.03). In the early stages of the disease, lymphocyte counts did not significantly decline but neutrophils counts did in children compared with adults (p=0.00). There was an elevated level of LDH(p=0.01) and a lower level of CRP(p=0.00)and IL-6(p=0.01) in children compared with adults.

Conclusions: The clinical symptoms of children are mild, and the positive indicators of laboratory tests are rare, which may easily cause clinical misdiagnoses.

Funding Statement: The authors stated: "None."

Declaration of Interests: The authors have no conflicts of interest to disclose.

Ethics Approval Statement: The project was approved by the ethics board of Jinan infectious hospital (No.20200203).

Keywords: Severe Acute Respiratory Syndrome Coronavirus-2; coronavirus disease 2019; Children; clinical characteristics

Suggested Citation

Du, Wenjun and Yu, Jinhong and Wang, Hui and Zhang, Xiaoguo and Zhang, Shouwei and Li, Qiang and Zhang, Zhongfa, Clinical Characteristics of COVID-19 in Children Compared with Adults Outside of Hubei Province in China (2/27/2020). Available at SSRN: https://ssrn.com/abstract=3546097 or http://dx.doi.org/10.2139/ssrn.3546097

Wenjun Du

Shandong University - Jinan Infectious Diseases Hospital ( email )

Jinan, 250012
China

Jinhong Yu

Shandong University - Jinan Infectious Diseases Hospital

Jinan, 250012
China

Hui Wang

Rizhao People's Hospital - Department of Infectious Diseases

Rizhao
China

Xiaoguo Zhang

Shandong University - Jinan Infectious Diseases Hospital

Jinan, 250012
China

Shouwei Zhang

Rizhao People's Hospital - Department of Infectious Diseases

Rizhao
China

Qiang Li

Shandong University - Jinan Infectious Diseases Hospital

Jinan, 250012
China

Zhongfa Zhang (Contact Author)

Shandong University - Jinan Infectious Diseases Hospital ( email )

Jinan, 250012
China

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