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Characteristics of Respiratory Virus Infection During the Outbreak of 2019 Novel Coronavirus in Beijing

20 Pages Posted: 10 Mar 2020

See all articles by Yan Li

Yan Li

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Jiangshan Wang

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Chunting Wang

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Qiwen Yang

Chinese Academy of Medical Sciences - Department of Clinical Laboratory

Yingchun Xu

Chinese Academy of Medical Sciences - Department of Clinical Laboratory

Jun Xu

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Yi Li

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Xuezhong Yu

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Huadong Zhu

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Jihai Liu

Chinese Academy of Medical Sciences - Department of Emergency Medicine

More...

Abstract

Background: 2019 novel coronavirus (2019-nCoV) is spreading in China and the disease was named as COVID-19, short for “coronavirus disease 2019”. However, other respiratory viruses also cause similar symptoms as COVID-19 does. Here, we summarized the composition of pathogens in fever clinic patients and analyzed characteristics of different respiratory viruses infection.

Methods: Retrospectively collected patients with definite etiological results using nasal and pharyngeal swabs in fever clinic. Epidemiologic features, clinical presentation, laboratory findings and image features were collected and analyzed.

Results: Totally, 1860 patients were screened and 136 patients were enrolled in the study. 72 (52.94%) of them were diagnosed as influenza (Flu) A virus infection. 32 (23.53%) of the patients were diagnosed as Flu B virus infection. 18 (13.24%) and 14 (10.29%) of the patients were diagnosed as COVID-19 and respiratory syncytial virus (RSV) infection respectively. COVID-19 group had a higher rate of contact with epidemic area within 14 days and clustering onset than other groups (P<0.05). Fever was the most common symptom in the respiratory virus infection patients. The ratio of fever and the highest temperature were higher in Flu A virus infection patients than in COVID-19 patients (P<0.05). COVID-19 patients had lower white blood cell (WBC) count and neutrophil count than Flu A virus and RSV infection group (P<0.05), but higher lymphocyte count than Flu A and B virus infection groups (P<0.05). C-reactive protein was higher in RSV infection group than in COVID-19 and Flu B infection group, but was not statistically different in Flu A and B infection and COVID-19 groups. COVID-19 group (83.33%) had a higher rate of pneumonia in chest CT scan than Flu A and B virus infection group (P<0.05).

Conclusions: Influenza viruses accounted for a large proportion of respiratory virus infection even during the epidemic of 2019-nCoV. No single symptom or laboratory finding was suggestive of a specific respiratory virus, however, epidemic history was important to the screening of COVID-19.

Funding Statement: The study was funded by CAMS Innovation Fund for Medical Sciences (2017- I2M-1-009).

Declaration of Interests: The authors stated: "None."

Ethics Approval Statement: This study was approved by the institutional review board committee of Peking Union Medical College Hospital and informed consent was taken from all the patients.

Keywords: 2019 novel coronavirus; COVID-19; influenza; virus; infection

Suggested Citation

Li, Yan and Wang, Jiangshan and Wang, Chunting and Yang, Qiwen and Xu, Yingchun and Xu, Jun and Li, Yi and Yu, Xuezhong and Zhu, Huadong and Liu, Jihai, Characteristics of Respiratory Virus Infection During the Outbreak of 2019 Novel Coronavirus in Beijing (2/29/2020). Available at SSRN: https://ssrn.com/abstract=3548768 or http://dx.doi.org/10.2139/ssrn.3548768

Yan Li

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Beijing
China

Jiangshan Wang

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Beijing
China

Chunting Wang

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Beijing
China

Qiwen Yang

Chinese Academy of Medical Sciences - Department of Clinical Laboratory

NO. 9, Dongdan Santiao
Beijing, Dongcheng District
China

Yingchun Xu

Chinese Academy of Medical Sciences - Department of Clinical Laboratory

NO. 9, Dongdan Santiao
Beijing, Dongcheng District
China

Jun Xu

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Beijing
China

Yi Li

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Beijing
China

Xuezhong Yu

Chinese Academy of Medical Sciences - Department of Emergency Medicine

Beijing
China

Huadong Zhu (Contact Author)

Chinese Academy of Medical Sciences - Department of Emergency Medicine ( email )

Beijing
China

Jihai Liu

Chinese Academy of Medical Sciences - Department of Emergency Medicine ( email )

Beijing
China

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