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Epidemiological and Clinical Features of Corona Virus Disease 2019 (COVID-19) in Changsha, China

24 Pages Posted: 10 Mar 2020

See all articles by Guyi Wang

Guyi Wang

Central South University - Department of Critical Care Medicine

Chenfang Wu

Central South University - Department of Critical Care Medicine

Quan Zhang

The First Hospital of Changsha - Department of Critical Care Medicine

Fang Wu

Central South University - Department of Medical Oncology; University of South China

Bo Yu

Central South University - Department of Critical Care Medicine

Jianlei Lv

The First Hospital of Changsha - Department of Critical Care Medicine

Yiming Li

Wuhan University - Department of Critical Care Medicine

Tiao Li

Central South University - Department of Respiratory Medicine

Chao Wu

Central South University - Department of Endocrinology and Metabolism

Guobao Wu

Central South University - Department of Critical Care Medicine

Yanjun Zhong

Central South University - Department of Critical Care Medicine

More...

Abstract

Background: The epidemiological and clinical characteristics of corona virus disease 2019 (COVID-19) patients in the cities near to Wuhan remain not very clear.

Methods: The epidemiological and clinical data of COVID-19 patients hospitalized in the Public Health Treatment Center of Changsha, China were collected and analyzed.

Findings: Of 242 hospitalized patients with COVID-19, the median age was 45 years old (range, 1-84 years) and 50.8% were women. 41.3% had a Wuhan exposure history, of which one had a Huanan seafood market exposure history. Three medical staff were infected, of which only one doctor's infection was deemed to be medical work-related. Thirty-seven patients (15.3%) were severe. Compared with non-severe patients, severe cases were older (median age, 57 vs 41 years) and had a higher incidence of underlying comorbidities, including hypertension and diabetes. Severe patients had lower lymphocytes, as well as higher levels of C-reactive protein, erythrocyte sedimentation rate and higher ratio of elevated PCT than non-severe patients. Patients with a short stay in Wuhan had a higher risk of being severe than those without Wuhan exposure. However, there were no significant differences in symptoms, laboratory findings, or underlying comorbidities between different groups according to Wuhan exposure history.

Interpretation: This is the first time to describe the epidemiological and clinical features of COVID-19 in the nearest capital cities around Wuhan. Wuhan city lockdown was effective in blocking the spread of COVID-19 outside Wuhan. Patients with short-termed Wuhan exposure history may be severer than those without Wuhan exposure.

Funding Statement: Not available.

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: This case series were approved by the institutional ethics board of the second Xiangya Hospital of Central South University (No. 2020001).

Keywords: novel coronovirus; 2019 novel coronavirus; 2019-nCoV; Wuhan exposure

Suggested Citation

Wang, Guyi and Wu, Chenfang and Zhang, Quan and Wu, Fang and Yu, Bo and Lv, Jianlei and Li, Yiming and Li, Tiao and Wu, Chao and Wu, Guobao and Zhong, Yanjun, Epidemiological and Clinical Features of Corona Virus Disease 2019 (COVID-19) in Changsha, China (3/1/2020). Available at SSRN: https://ssrn.com/abstract=3548770 or http://dx.doi.org/10.2139/ssrn.3548770

Guyi Wang

Central South University - Department of Critical Care Medicine

Changsha
China

Chenfang Wu

Central South University - Department of Critical Care Medicine

Changsha
China

Quan Zhang

The First Hospital of Changsha - Department of Critical Care Medicine

Changsha
China

Fang Wu

Central South University - Department of Medical Oncology

China

University of South China

Hunan Sheng, Hengyang Shi
Zhengxiang Qu
China

Bo Yu

Central South University - Department of Critical Care Medicine

Changsha
China

Jianlei Lv

The First Hospital of Changsha - Department of Critical Care Medicine

Changsha
China

Yiming Li

Wuhan University - Department of Critical Care Medicine

Wuhan, 430071
China

Tiao Li

Central South University - Department of Respiratory Medicine

Changsha
China

Chao Wu

Central South University - Department of Endocrinology and Metabolism

Changsha, Hunan 410011
China

Guobao Wu

Central South University - Department of Critical Care Medicine

Changsha
China

Yanjun Zhong (Contact Author)

Central South University - Department of Critical Care Medicine ( email )

Changsha
China

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