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Clinical Findings of Patients with Coronavirus Disease 2019 in Jiangsu Province, China: A Retrospective, Multi-Center Study

33 Pages Posted: 10 Mar 2020

See all articles by Rui Huang

Rui Huang

Nanjing University - Department of Infectious Diseases

Li Zhu

Soochow University - Department of Infectious Diseases

Leyang Xue

The Fourth Hospital of Huai'an - Department of Critical Medicine

Longgen Liu

Government of the People's Republic of China - Changzhou Third People's Hospital

Xuebing Yan

Xuzhou Medical University - Department of Infectious Diseases

Jian Wang

Nanjing University - Department of Infectious Diseases

Biao Zhang

The Fourth Hospital of Huai'an - Department of Quality Control Office

Tianmin Xu

Third People's Hospital of Changzhou - Department of Infectious Diseases

Fang Ji

Xuzhou Medical University - Department of Infectious Diseases

Yun Zhao

Third People’s Hospital of Yangzhou - Department of Infectious Diseases

Juan Cheng

Yancheng Second People’s Hospital - Department of Infectious Diseases

Yinling Wang

Soochow University - Department of Infectious Diseases

Huaping Shao

Nanjing Gulou Hospital Group - Department of Infectious Diseases

Shuqin Hong

The Fourth Hospital of Huai'an - Nursing Department

Qi Cao

Third People's Hospital of Changzhou - Department of Infectious Diseases

Chunyang Li

Xuzhou Medical University - Department of Infectious Diseases

Xiang-an Zhao

Yangzhou University - Department of Gastroenterology

Lei Zou

Yancheng Second People’s Hospital - Department of Infectious Diseases

Dawen Sang

Yancheng Second People’s Hospital - Department of Infectious Diseases

Haiyan Zhao

Nanjing Gulou Hospital Group - Department of Infectious Diseases

Xinying Guan

Lianyungang First People's Hospital - Department of Neurology

Xiaobing Chen

Lianyungang First People's Hospital - Department of Emergency

Chun Shan

Southeast University (China) - Department of Infectious Diseases

Juan Xia

Nanjing University - Department of Infectious Diseases

Yuxin Chen

Nanjing University - Department of Laboratory Medicine and Infectious Diseases

Xiaomin Yan

Nanjing University - Department of Infectious Diseases

Jie Wei

Nanjing University - Department of Infectious Diseases

Chuanwu Zhu

Soochow University - Department of Infectious Diseases

Chao Wu

Nanjing University - Department of Infectious Diseases

More...

Abstract

Background: Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside of Wuhan. This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China.

Methods: Clinical data of hospitalized COVID-19 patients were retrospectively collected in ten hospitals from nine cities of Jiangsu province, China. Clinical findings of COVID-19 patients were described and risk factors for severe illness of COVID-19 were analyzed.

Findings: By Feb 10, 2020, 221 hospitalized patients with COVID-19 were enrolled. The median age of patients was 45.0 years (interquartile range, 33.5–56.0). 60 (27.1%) patients had comorbidities. At onset of illness, the common symptoms were fever (171 [77.4%]) and cough (133 [60.2%]). 68 (30.8%) patients had lymphopenia. 211 (95.5%) patients had abnormal radiological findings. 11 (5.0%) patients were admitted to the intensive care unit and none of the patients died. 25 (11.3%) patients had severe illness. Severe illness of COVID-19 was independently associated with body mass index (BMI)≥28 kg/m 2 (odds ratio [OR], 5.872; 95% confidence interval [CI], 1.595 to 21.621; P=0.008) and a known history of type 2 diabetes (OR, 7.033; 95% CI, 1.908 to 25.921; P=0.003).

Interpretation: In this case series in Jiangsu Province, COVID-19 patients have less severe symptoms and have better outcomes than the initial COVID-19 patients in Wuhan. The BMI ≥ 28 kg/m 2 and a known history of type 2 diabetes are independent risk factors of severe illness in patients with COVID-19.

Funding Statement: None.

Declaration of Interests: All authors declare no competing interests.

Ethics Approval Statement: The study was approved by the institutional ethics board of these hospitals, with a waiver of informed consent.

Suggested Citation

Huang, Rui and Zhu, Li and Xue, Leyang and Liu, Longgen and Yan, Xuebing and Wang, Jian and Zhang, Biao and Xu, Tianmin and Ji, Fang and Zhao, Yun and Cheng, Juan and Wang, Yinling and Shao, Huaping and Hong, Shuqin and Cao, Qi and Li, Chunyang and Zhao, Xiang-an and Zou, Lei and Sang, Dawen and Zhao, Haiyan and Guan, Xinying and Chen, Xiaobing and Shan, Chun and Xia, Juan and Chen, Yuxin and Yan, Xiaomin and Wei, Jie and Zhu, Chuanwu and Wu, Chao, Clinical Findings of Patients with Coronavirus Disease 2019 in Jiangsu Province, China: A Retrospective, Multi-Center Study (2/28/2020). Available at SSRN: https://ssrn.com/abstract=3548785 or http://dx.doi.org/10.2139/ssrn.3548785

Rui Huang (Contact Author)

Nanjing University - Department of Infectious Diseases

Nanjing
China

Li Zhu

Soochow University - Department of Infectious Diseases

Suzhou
China

Leyang Xue

The Fourth Hospital of Huai'an - Department of Critical Medicine

Huai’an
China

Longgen Liu

Government of the People's Republic of China - Changzhou Third People's Hospital

Changzhou
China

Xuebing Yan

Xuzhou Medical University - Department of Infectious Diseases

Xuzhou
China

Jian Wang

Nanjing University - Department of Infectious Diseases

Nanjing
China

Biao Zhang

The Fourth Hospital of Huai'an - Department of Quality Control Office

Huai’an
China

Tianmin Xu

Third People's Hospital of Changzhou - Department of Infectious Diseases

Changzhou
China

Fang Ji

Xuzhou Medical University - Department of Infectious Diseases

Xuzhou
China

Yun Zhao

Third People’s Hospital of Yangzhou - Department of Infectious Diseases

Yangzhou
China

Juan Cheng

Yancheng Second People’s Hospital - Department of Infectious Diseases

Yancheng
China

Yinling Wang

Soochow University - Department of Infectious Diseases

Suzhou
China

Huaping Shao

Nanjing Gulou Hospital Group - Department of Infectious Diseases

Suqian
China

Shuqin Hong

The Fourth Hospital of Huai'an - Nursing Department

Huai’an
China

Qi Cao

Third People's Hospital of Changzhou - Department of Infectious Diseases

Changzhou
China

Chunyang Li

Xuzhou Medical University - Department of Infectious Diseases

Xuzhou
China

Xiang-an Zhao

Yangzhou University - Department of Gastroenterology

Yangzhou
China

Lei Zou

Yancheng Second People’s Hospital - Department of Infectious Diseases

Yancheng
China

Dawen Sang

Yancheng Second People’s Hospital - Department of Infectious Diseases

Yancheng
China

Haiyan Zhao

Nanjing Gulou Hospital Group - Department of Infectious Diseases

Suqian
China

Xinying Guan

Lianyungang First People's Hospital - Department of Neurology

Lianyungang
China

Xiaobing Chen

Lianyungang First People's Hospital - Department of Emergency

Lianyungang
China

Chun Shan

Southeast University (China) - Department of Infectious Diseases

Nanjing
China

Juan Xia

Nanjing University - Department of Infectious Diseases

Nanjing
China

Yuxin Chen

Nanjing University - Department of Laboratory Medicine and Infectious Diseases

Nanjing
China

Xiaomin Yan

Nanjing University - Department of Infectious Diseases

Nanjing
China

Jie Wei

Nanjing University - Department of Infectious Diseases

Nanjing
China

Chuanwu Zhu

Soochow University - Department of Infectious Diseases ( email )

Suzhou
China

Chao Wu

Nanjing University - Department of Infectious Diseases ( email )

Nanjing
China

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