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Epidemiological Feature and Outcome of 292 Hospitalized Patients with COVID-19 Under Adequate Medical Resource Condition

27 Pages Posted: 13 Mar 2020

See all articles by Xiang Li

Xiang Li

Sun Yat-Sen University (SYSU) - Department of Spine Surgery

Yue Hu

Sun Yat-Sen University (SYSU) - Research Center of Translational Medicine

Shunye Zhu

Sun Yat-Sen University (SYSU) - Department of Pediatrics

Yueping Li

Guangzhou Medical University - Department of Intensive Care Unit

Ling Huang

Sun Yat-Sen University (SYSU) - The Reproductive Center

Yubin Li

Sun Yat-Sen University (SYSU) - The Reproductive Center

Lingli Long

Sun Yat-Sen University (SYSU) - Translation Medicine Center

More...

Abstract

Background: In December 2019, a novel acute respiratory disease occurred in Wuhan, the capital of Hubei Province, China. Demographic data of COVID-19 patients in regions with adequate medical resource is scarce. Thus, we aim to describe the clinical characteristics and outcome of 292 confirmed patients in regions with adequate medical resource, and discussed the difference clinical characteristics, therapeutic effect and outcome between patients with and without underlying diseases.

Method: COVID-19 case reports by NHC and WHO were analyzed. The epidemiological features of COVID-19 and medical resources were compared between Hubei and regions outside Hubei. Total 292 patients with COVID-19 in Guangzhou were enrolled. The epidemiological and demographic data including basic information (sex, aged, etc), laboratory values, clinical outcome of patients were recorded and analyzed. The epidemiological feature and clinical outcome were compared between patients with and without underlying diseases.

Finding: The deteriorating condition of 2019-nCoV in Wuhan-Hubei related to inadequate medical resource. Under the adequate medical condition, 15·41% of 292 laboratory-confirmed cases patients are critical illness, 15·56% critical patients need mechanical ventilation, and 33·33% critical patients are cured after average 10 days in ICU. Patients without underlying diseases shows higher cured rate (113 [61·50%] patients vs 46 [42·20%] patients) and lower critical rate (26 [23·85%] patients vs 19 [10·38%] patients) than patients with underlying diseases.

Interpretation: This study suggested that early prevention and preparation of adequate medical source can prevent the outbreak of 2019-nCoV. Furthermore, our study gives clinical clues that physician should pay more attention on patients with underlying diseases, especially patients with poor lung function.

Funding Statement: None.

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: This study was approved by the Institutional Ethics Board of the First Affiliated Hospital of Sun Yat-sen University.

Keywords: COVID-19; 2019-nCoV

Suggested Citation

Li, Xiang and Hu, Yue and Zhu, Shunye and Li, Yueping and Huang, Ling and Li, Yubin and Long, Lingli, Epidemiological Feature and Outcome of 292 Hospitalized Patients with COVID-19 Under Adequate Medical Resource Condition (3/2/2020). Available at SSRN: https://ssrn.com/abstract=3550016 or http://dx.doi.org/10.2139/ssrn.3550016

Xiang Li

Sun Yat-Sen University (SYSU) - Department of Spine Surgery

Guangzhou, 510080
China

Yue Hu

Sun Yat-Sen University (SYSU) - Research Center of Translational Medicine

135, Xingang Xi Road
Guangzhou, Guangdong 510275
China

Shunye Zhu

Sun Yat-Sen University (SYSU) - Department of Pediatrics

Guangzhou, 510630
China

Yueping Li

Guangzhou Medical University - Department of Intensive Care Unit

Guangzhou, 510060
China

Ling Huang

Sun Yat-Sen University (SYSU) - The Reproductive Center

Guangzhou, 510080
China

Yubin Li

Sun Yat-Sen University (SYSU) - The Reproductive Center ( email )

Guangzhou, 510080
China

Lingli Long (Contact Author)

Sun Yat-Sen University (SYSU) - Translation Medicine Center ( email )

Guangzhou, 510080
China

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