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Novel Coronavirus (2019-nCoV) Infection in Humans: A Scoping Review and Meta-Analysis

65 Pages Posted: 13 Mar 2020

See all articles by Israel Junior Borges do Nascimento

Israel Junior Borges do Nascimento

Federal University of Minas Gerais (UFMG) - University Hospital

Ana Marusic

University of Split - School of Medicine

Nensi Cacic

University of Split - School of Medicine

Hebatullah Mohamed Abdulazeem

Technische Universität München (TUM) - Department of Sport and Health Science

Meisam Abdar Esfahani

National Institute for Medical Research Development - Cochrane Iran Associate Centre

Umesh Jayarajah

University of Colombo - Department of Surgery

Ana Jeroncic

University of Split - School of Medicine

Vinicius Tassoni Civile

Federal University of São Paulo (UNIFESP) - Evidence-Based Health Program

Nelson Carvas Junior

Universidade Paulista - UNIP

Thilo Caspar von Groote

University of Münster - Department of Anaesthesiology, Intensive Care and Pain Medicine

Ishanka Weerasekara

University of Peradeniya - Department of Physiotherapy

Tina Poklepovic Pericic

University of Split - School of Medicine

Irena Zakarija-Grkovic

University of Split - School of Medicine

Silvana Mangeon Meirelles Guimarães

Federal University of Minas Gerais (UFMG) - University Hospital

Nicola Luigi Bragazzi

York University - Laboratory for Industrial and Applied Mathematics

Maria Bjorklund

Lund University - Faculty of Medicine

Ahmad Sofi-Mahmudi

National Institute for Medical Research Development - Cochrane Iran Associate Centre

Mohammad Altujjar

University of Toledo - Department of Internal Medicine

Maoyi Tian

University of New South Wales (UNSW) - Faculty of Medicine

Diana Maria Cespedes Arcani

Wuhan University - Department of Cardiovascular and Thoracic Surgery

Milena Soriano Marcolino

Federal University of Minas Gerais (UFMG) - University Hospital

More...

Abstract

Background: A growing body of literature on the 2019 novel coronavirus (2019-nCoV) is becoming available but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the 2019-nCoV infection.

Methodology: We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from January 1st, 2019 to February 24th, 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis was conducted, and random-effects models were applied to estimate pooled results.

Findings: Sixty-one studies were included (101,905 patients). The most common disease-related symptoms were fever (84%, 95% confidence interval (CI) 77-91%; n=2,452), cough (63%, 95% CI 55-70%; n=2,027), and muscle aches and/or fatigue (27%, 95% CI 19-37%; n=1,742). Laboratory findings were described in a lower number of patients, and revealed lymphopenia (0.93x109/L, 95% CI 0.83-1.03x109/L, n=464) and abnormal C-reactive protein (33.72mg/dL, 95% CI 21.54-45.91mg/dL, n=1637). Radiological findings varied, but mostly described ground glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 1.1% (95% CI 0.1-2.7%; n=51,673). Epidemiological studies showed that mortality was higher in males and elderly patients.

Interpretation: The majority of reported clinical symptoms and laboratory findings related to 2019-nCoV infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.

Funding Statement: No funding was obtained for this study.

Declaration of Interests: None.

Ethics Approval Statement: The authors stated that ethics approval was not necessary.

Keywords: Coronavirus; Evidence-based Medicine; Symptom Assessment; public health; 2019- nCoV

Suggested Citation

Borges do Nascimento, Israel Junior and Marusic, Ana and Cacic, Nensi and Mohamed Abdulazeem, Hebatullah and Abdar Esfahani, Meisam and Jayarajah, Umesh and Jeroncic, Ana and Tassoni Civile, Vinicius and Carvas Junior, Nelson and von Groote, Thilo Caspar and Weerasekara, Ishanka and Poklepovic Pericic, Tina and Zakarija-Grkovic, Irena and Meirelles Guimarães, Silvana Mangeon and Bragazzi, Nicola Luigi and Bjorklund, Maria and Sofi-Mahmudi, Ahmad and Altujjar, Mohammad and Tian, Maoyi and Cespedes Arcani, Diana Maria and Soriano Marcolino, Milena, Novel Coronavirus (2019-nCoV) Infection in Humans: A Scoping Review and Meta-Analysis (3/3/2020). Available at SSRN: https://ssrn.com/abstract=3550028 or http://dx.doi.org/10.2139/ssrn.3550028

Israel Junior Borges do Nascimento (Contact Author)

Federal University of Minas Gerais (UFMG) - University Hospital ( email )

Belo Horizonte
Brazil

Ana Marusic

University of Split - School of Medicine

Split
Croatia

Nensi Cacic

University of Split - School of Medicine

Split
Croatia

Hebatullah Mohamed Abdulazeem

Technische Universität München (TUM) - Department of Sport and Health Science

Munich
Germany

Meisam Abdar Esfahani

National Institute for Medical Research Development - Cochrane Iran Associate Centre

Tehran
Iran

Umesh Jayarajah

University of Colombo - Department of Surgery

Colombo
Sri Lanka

Ana Jeroncic

University of Split - School of Medicine

Split
Croatia

Vinicius Tassoni Civile

Federal University of São Paulo (UNIFESP) - Evidence-Based Health Program

São Paulo
Brazil

Nelson Carvas Junior

Universidade Paulista - UNIP

Sao Paulo, SP
Brazil

Thilo Caspar Von Groote

University of Münster - Department of Anaesthesiology, Intensive Care and Pain Medicine

Münster
Germany

Ishanka Weerasekara

University of Peradeniya - Department of Physiotherapy

Peradeniya
Sri Lanka

Tina Poklepovic Pericic

University of Split - School of Medicine

Split
Croatia

Irena Zakarija-Grkovic

University of Split - School of Medicine

Split
Croatia

Silvana Mangeon Meirelles Guimarães

Federal University of Minas Gerais (UFMG) - University Hospital

Belo Horizonte
Brazil

Nicola Luigi Bragazzi

York University - Laboratory for Industrial and Applied Mathematics

Canada

Maria Bjorklund

Lund University - Faculty of Medicine

Box 117
SE-221 00 Lund
Sweden

Ahmad Sofi-Mahmudi

National Institute for Medical Research Development - Cochrane Iran Associate Centre

Tehran
Iran

Mohammad Altujjar

University of Toledo - Department of Internal Medicine

Toledo, OH
United States

Maoyi Tian

University of New South Wales (UNSW) - Faculty of Medicine

Australia

Diana Maria Cespedes Arcani

Wuhan University - Department of Cardiovascular and Thoracic Surgery

Hubei
China

Milena Soriano Marcolino

Federal University of Minas Gerais (UFMG) - University Hospital

Belo Horizonte
Brazil

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