Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact email@example.com.
A Survey for COVID-19 Among HIV/AIDS Patients in Two Districts of Wuhan, China
19 Pages Posted: 13 Mar 2020More...
Background: There were over 49 thousand Coronavirus infected diseases-19(COVID-19) patients in Wuhan city, Hubei province, China, the center of epidemic of the disease. Over 5000 HIV/AIDS patients live in Wuhan. No data on the morbidity of COVID-19 in HIV/AIDS patients have been published to date.
Methods: In this study, we investigated 1178 HIV/AIDS patients in two central districts in Wuhan city. Whether they have any clinical presentations and whether they contacted any confirmed COVID-19 patients were inquired. The results for nucleic acid test (NAT) of SARS-CoV-2 and CT scan in those with clinical symptoms or contact history were investigated. The antiretroviral regimens of all these patients and other information, like age, sex, CD4+T cell counts (CD4 counts), HIV viral load (HIV-VL) were also collected. The risk factors for the COVID-19 in HIV/AIDS patients were analyzed.
Findings: We found 12 individuals in 1174 HIV/AIDS patients who presented clinical symptoms, and 8 of them were confirmed COVID-19. Six of them were NAT confirmed SARS-CoV-2 infection, and 2 were clinical confirmed cases. Six of the 8 COVID-19 patients had CD4 counts> 350/µl, and 2 with CD4 counts between 101-350/µl. All of the 8 patients have a low HIV-VL＜20 copies/ml. The older age is the risk factor to occur COVID-19 in HIV/AIDS. All the 8 COVID-19 patients were from 947 individuals (0.84%) who took NRTI+NNRTI as antiretroviral regimen. In those who have no symptoms, there were another 9 HIV/AIDS patients had close contact with confirmed COVID-19 patients, and only 1 of them was confirmed positive by NAT.
Interpretation: Our findings indicated that the compromised immunity might be the reason that HIV/AIDS patients did not occur inflammatory changes and clinical symptoms, which support the early usage of corticosteroids in treatment for COVID-19. At the same time, the usage of LPV/r may potentially help to prevent or treat COVID-19.
Funding Statement: This work was supported by the grant of the National Natural Science Foundation of China (81471940) to Y.F.
Declaration of Interests: The authors declare no conflict of interest.
Ethics Approval Statement: This study was approved by the Zhongnan Hospital of Wuhan University Institutional Review Board and the need for informed consent was waived.
Keywords: COVID-19; HIV/AIDS; SARS-CoV-2; Survey; Wuhan
Suggested Citation: Suggested Citation