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The Virological and Epidemiological Features of COVID-19 in Anhui, China

21 Pages Posted: 30 Mar 2020

See all articles by Jun He

Jun He

Anhui Provincial Center for Disease Control and Prevention

Yong Sun

Anhui Provincial Center for Disease Control and Prevention

Lijie Wang

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - State Key Laboratory of Infectious Disease Prevention and Control

Jiabing Wu

Anhui Provincial Center for Disease Control and Prevention

Lei Gong

Anhui Provincial Center for Disease Control and Prevention

Sai Hou

Anhui Provincial Center for Disease Control and Prevention

Junling Yu

Anhui Provincial Center for Disease Control and Prevention

Qingqing Chen

Anhui Provincial Center for Disease Control and Prevention

Weiwei Li

Anhui Provincial Center for Disease Control and Prevention

Yuan Yuan

Anhui Provincial Center for Disease Control and Prevention

Yonglin Shi

Anhui Provincial Center for Disease Control and Prevention

Yongjun Gao

Chinese Center for Disease Control and Prevention (China CDC) - NHC Key Laboratory of Biosafety

Zhuhui Zhang

Anhui Provincial Center for Disease Control and Prevention

Meng Zhu

Anhui Provincial Center for Disease Control and Prevention

Lan He

Anhui Provincial Center for Disease Control and Prevention

Yinglu Ge

Anhui Provincial Center for Disease Control and Prevention

Weidong Li

Anhui Provincial Center for Disease Control and Prevention

Zhirong Liu

Anhui Provincial Center for Disease Control and Prevention

Rongbao Gao

Chinese Center for Disease Control and Prevention - Key Laboratory of Medical Virology

More...

Abstract

Background: SARS-CoV-2 has caused a huge outbreak in China and multiple countries since it emerged in Wuhan, China in December, 2019. The virus caused diseases (COVID-19) has raised world concern because of rapid transmissibility, high mobility and mortality.

Methods: Field investigations were conducted for 914 confirmed patients with COVID-19 in Anhui province, China. Patients were confirmed to be infected with SARS-CoV-2 by real-time RT-PCR (rRT-PCR). Information on demographic characteristics, and exposure history was obtained from patients with confirmed cases. We conducted virological and epidemiological analysis on these patients.

Findings: The rRT-PCR Ct values were remarkably lower in sputum samples than throat swab samples. The virus was detected with a low Ct value at early or late stage of illness, even at the day of illness onset or day 20 after illness onset in individual patients. Ct values didn’t show a significant association with incidence of severity at early stage of illness or grouped ages. Male, older patients and delayed diagnosis showed positive association with enhancing severity of COVID-19 but increased generation of infection was negative association with the enhancing severity.

Interpretation: Viral load was not related to the severity of COVID-19 in early stage of COVID-19. Male and delayed diagnosis increased a risk of enhancing COVID-19 severity while decreased the risk with increasing generation of infection. SARS-CoV-2 may increase human-to-human transmissibility through long term replication within individual human host.

Funding Statement: This work was supported by the National Mega-projects for Infectious Diseases (grant numbers 2017ZX10304402-001-019) and National Natural Scientific Foundation of China (grant numbers 81971946). Emergency research project of novel coronavirus infection of Anhui province (grant numbers 202004a07020002; 202004a07020004).

Declaration of Interests: None.

Ethics Approval Statement: Data collection and analysis of cases and close contacts were determined by the National Health Commission of the People’s Republic of China to be part of a continuing public health outbreak investigation and were thus considered exempt from institutional review board approval.

Keywords: COVID-19; SARS-CoV-19; Viral load; Transmission

Suggested Citation

He, Jun and Sun, Yong and Wang, Lijie and Wu, Jiabing and Gong, Lei and Hou, Sai and Yu, Junling and Chen, Qingqing and Li, Weiwei and Yuan, Yuan and Shi, Yonglin and Gao, Yongjun and Zhang, Zhuhui and Zhu, Meng and He, Lan and Ge, Yinglu and Li, Weidong and Liu, Zhirong and Gao, Rongbao, The Virological and Epidemiological Features of COVID-19 in Anhui, China (3/7/2020). Available at SSRN: https://ssrn.com/abstract=3551351 or http://dx.doi.org/10.2139/ssrn.3551351

Jun He (Contact Author)

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Yong Sun

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Lijie Wang

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - State Key Laboratory of Infectious Disease Prevention and Control

155 Changbai Road
Changping District
Beijing, 102206
China

Jiabing Wu

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Lei Gong

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Sai Hou

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Junling Yu

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Qingqing Chen

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Weiwei Li

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Yuan Yuan

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Yonglin Shi

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Yongjun Gao

Chinese Center for Disease Control and Prevention (China CDC) - NHC Key Laboratory of Biosafety

Beijing
China

Zhuhui Zhang

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Meng Zhu

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Lan He

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Yinglu Ge

Anhui Provincial Center for Disease Control and Prevention

Hefei, 12560
China

Weidong Li

Anhui Provincial Center for Disease Control and Prevention ( email )

Hefei, 12560
China

Zhirong Liu

Anhui Provincial Center for Disease Control and Prevention ( email )

Hefei, 12560
China

Rongbao Gao

Chinese Center for Disease Control and Prevention - Key Laboratory of Medical Virology ( email )

China

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