lancet-header
Preprints with The Lancet is part of SSRN´s First Look, a place where journals and other research experts identify content of interest prior to publication. These preprint papers are not peer-reviewed and are posted here as part of a 12-month trial. Authors have either opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet, or submitted directly via SSRN. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. These papers should not be used for clinical decision making or reporting of research to a lay audience without indicating that this is preliminary research that has not been peer-reviewed. For more information see the Comment published in The Lancet, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com

Clinical Features of Stool SARS-CoV-2 RNA Positive in 137 COVID-19 Patients in Taizhou, China

14 Pages Posted: 23 Mar 2020

See all articles by Jiaxi Chen

Jiaxi Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Hongguo Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Donglian Wang

Wenzhou Medical University - Affiliated Taizhou Hospital

Yufen Zheng

Wenzhou Medical University - Affiliated Taizhou Hospital

Jiaqin Xu

Wenzhou Medical University - Affiliated Taizhou Hospital

Guangjun Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Qinxin Shi

Wenzhou Medical University - Affiliated Taizhou Hospital

Yang Lu

Wenzhou Medical University - Affiliated Taizhou Hospital

Ying Zhang

Wenzhou Medical University - Affiliated Taizhou Hospital

Jun Li

Wenzhou Medical University - Affiliated Taizhou Hospital

Shiyong Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Xianhong Ding

Wenzhou Medical University - Affiliated Taizhou Hospital

Chong Liu

Wenzhou Medical University - Affiliated Taizhou Hospital

Bingjie Hu

Wenzhou Medical University - Affiliated Taizhou Hospital

Chenliang Hong

Wenzhou Medical University - Affiliated Taizhou Hospital

Xiangyu Xu

Wenzhou Medical University - Affiliated Taizhou Hospital

Zebao He

Wenzhou Medical University - Affiliated Taizhou Hospital

Haihong Zhao

Wenzhou Medical University - Affiliated Taizhou Hospital

Chao Zhang

Wenzhou Medical University - Affiliated Taizhou Hospital

Xiaomai Wu

Wenzhou Medical University - Affiliated Taizhou Hospital

Luxiao Hong

Wenzhou Medical University - Affiliated Taizhou Hospital

Hui Shao

Wenzhou Medical University - Affiliated Taizhou Hospital

Miaoguo Cai

Wenzhou Medical University - Affiliated Taizhou Hospital

Jiya Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Jiansheng Zhu

Wenzhou Medical University - Department of Infectious Diseases

Dongqing Lv

Wenzhou Medical University - Affiliated Taizhou Hospital

Baofu Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Bo Shen

Wenzhou Medical University - Affiliated Taizhou Hospital

More...

Abstract

Background: New coronavirus pneumonia (COVID-19) outbreak and caused global human respiratory tract infections since 2019, however, the pattern of SARS-CoV-2 intestinal tract infections is not well understood.

Methods: The virological and epidemiological researches prompted us to speculate that the human intestinal tract may serve as a supplementary route to acquire SARS-CoV-2 infection. By identifying the evidence of virus intestinal infection in 343 stool specimen and identifying the evidence of virus respiratory infection in 575 throat swabs samples in 137 clinical patient who were confirmed diagnosis with COVID-19 subsequently.

Results: As the largest stool samples and the longest monitoring time so far, our study demonstrated that in spite of the virus harbour in the respiratory tract earlier than intestinal tract as 106 patients (77%) showed the first throat swab virus positive and only 22 patients (16%) showed the first stool virus positive in the first 10 days after their disease onset respectively, however, SARS-CoV-2 would harbour in the both respiratory tract and intestinal tract for 10-14 days. In addition, many patients appeared stool RNA positive when their swab RNA had turn negative and we suggested that both throat swabs and stool specimens are needed to absolutely confirm the elimination of the SARS-CoV-2.

Conclusions: We addressed a scientific clinical evidence for the implementation of effective prevention measures to halt the continuing COVID-19 epidemic.

Funding Statement: This work is funded by China National Natural Youth Science Foundation (81802078), Zhejiang Province Analysis Test Project Foundation (2018C37032), Zhejiang Province Public Welfare Research Foundation (GF20H200021), Zhejiang Provincial Department of Medicine and Health Foundation ( 2018KY912/2019RC315/2019323341/2020KY371), Enze Medical Center (Group) Scientific Research Foundation(18EZA06/15EZC2) and Luqiao Science and Technology Bureau Foundation (2017A23005).

Declaration of Interests: All authors declare no competing interests.

Ethics Approval Statement: This study was approved by the Ethics Committee of Enze Medical Center (Group). Written informed consent was obtained from all patients enrolled into this study or their legal guardians.

Keywords: COVID-19; SARS-CoV-2; stool; swabs

Suggested Citation

Chen, Jiaxi and Zhu, Hongguo and Wang, Donglian and Zheng, Yufen and Xu, Jiaqin and Zhu, Guangjun and Shi, Qinxin and Lu, Yang and Zhang, Ying and Li, Jun and Chen, Shiyong and Ding, Xianhong and Liu, Chong and Hu, Bingjie and Hong, Chenliang and Xu, Xiangyu and He, Zebao and Zhao, Haihong and Zhang, Chao and Wu, Xiaomai and Hong, Luxiao and Shao, Hui and Cai, Miaoguo and Chen, Jiya and Zhu, Jiansheng and Lv, Dongqing and Chen, Baofu and Shen, Bo, Clinical Features of Stool SARS-CoV-2 RNA Positive in 137 COVID-19 Patients in Taizhou, China (3/4/2020). Available at SSRN: https://ssrn.com/abstract=3551383 or http://dx.doi.org/10.2139/ssrn.3551383

Jiaxi Chen (Contact Author)

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Hongguo Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Donglian Wang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Yufen Zheng

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jiaqin Xu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Guangjun Zhu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Qinxin Shi

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Yang Lu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Ying Zhang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jun Li

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Shiyong Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Xianhong Ding

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Chong Liu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Bingjie Hu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Chenliang Hong

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Xiangyu Xu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Zebao He

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Haihong Zhao

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Chao Zhang

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Xiaomai Wu

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Luxiao Hong

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Hui Shao

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Miaoguo Cai

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jiya Chen

Wenzhou Medical University - Affiliated Taizhou Hospital

Taizhou
China

Jiansheng Zhu

Wenzhou Medical University - Department of Infectious Diseases ( email )

150 Ximen Road of Linhai City
Taizhou
China

Dongqing Lv

Wenzhou Medical University - Affiliated Taizhou Hospital ( email )

Taizhou
China

Baofu Chen

Wenzhou Medical University - Affiliated Taizhou Hospital ( email )

Taizhou
China

Bo Shen

Wenzhou Medical University - Affiliated Taizhou Hospital ( email )

Taizhou
China

Click here to go to TheLancet.com

Paper statistics

Abstract Views
333
Downloads
63