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Overly Exuberant Innate Immune Response to SARS-CoV-2 Infection

31 Pages Posted: 24 Mar 2020 Sneak Peek Status: Under Review

See all articles by Zhuo Zhou

Zhuo Zhou

Peking University - Biomedical Pioneering Innovation Center (BIOPIC)

Lili Ren

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Li Zhang

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Jiaxin Zhong

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Yan Xiao

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Zhilong Jia

Government of the People's Republic of China - Key Laboratory of Biomedical Engineering and Translational Medicine

Li Guo

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Jing Yang

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Chun Wang

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Shuai Jiang

Chinese Academy of Sciences (CAS) - Beijing Institute of Genomics

Donghong Yang

Peking University - Department of Respiratory and Critical Care Medicine

Guoliang Zhang

Southern University of Science and Technology - National Clinical Research Center for Infectious Diseases

Hongru Li

Fujian Provincial Hospital

Fuhui Chen

Harbin Medical University - Department of Respiratory

Yu Xu

Peking University - Department of Respiratory and Critical Care Medicine

Mingwei Chen

Xi'an Jiaotong University (XJTU) - Department of Respiratory and Critical Care Medicine

Zhancheng Gao

Peking University - Department of Respiratory and Critical Care Medicine

Jian Yang

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Jie Dong

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Bo Liu

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Xiannian Zhang

Capital Medical University - Beijing Advanced Innovation Center for Human Brain Protection

Weidong Wang

Chinese PLA General Hospital - Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure

Kunlun He

Chinese PLA General Hospital - Beijing Key Laboratory for Precision Medicine of Chronic Heart

Qi Jin

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Mingkun Li

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Jianwei Wang

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

More...

Abstract

The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 infection has posed a severe threat to global public health. It is unclear how the human immune system responds to the virus infection. Here, we profiled the immune transcriptome signatures by metatranscriptome sequencing for the bronchoalveolar lavage fluid from eight COVID-19 cases. The expression of the proinflammatory genes, especially chemokines, was markedly elevated in COVID-19 cases as compared to community-acquired pneumonia patients and healthy controls, suggesting that SARS-CoV-2 infection caused hypercytokinemia. Contrasting with SARS-CoV, which is thought to induce inadequate interferon (IFN) response, SARS-CoV-2 robustly triggered the expression of myriad IFN-inducible genes (ISGs). These ISGs exhibit immunopathogenic potentials, characterized by the overrepresentation of genes involved in inflammation. Collectively, we profiled the molecular signatures of the host response to SARS-CoV-2 infection, which could help to understand the disease pathogenesis and provided clues for tailored antiviral strategies, such as IFN therapy.

Keywords: SARS-CoV-2, COVID-19, Innate immune response, Interferon, Interferon-stimulated gene, hypercytokinemia, immunopathogenesis

Suggested Citation

Zhou, Zhuo and Ren, Lili and Zhang, Li and Zhong, Jiaxin and Xiao, Yan and Jia, Zhilong and Guo, Li and Yang, Jing and Wang, Chun and Jiang, Shuai and Yang, Donghong and Zhang, Guoliang and Li, Hongru and Chen, Fuhui and Xu, Yu and Chen, Mingwei and Gao, Zhancheng and Yang, Jian and Dong, Jie and Liu, Bo and Zhang, Xiannian and Wang, Weidong and He, Kunlun and Jin, Qi and Li, Mingkun and Wang, Jianwei, Overly Exuberant Innate Immune Response to SARS-CoV-2 Infection. Available at SSRN: https://ssrn.com/abstract=3551623 or http://dx.doi.org/10.2139/ssrn.3551623
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Zhuo Zhou

Peking University - Biomedical Pioneering Innovation Center (BIOPIC)

Beijing, 100871
China

Lili Ren

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Beijing
China

Li Zhang

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Jiaxin Zhong

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Beijing
China

Yan Xiao (Contact Author)

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Beijing
China

Zhilong Jia

Government of the People's Republic of China - Key Laboratory of Biomedical Engineering and Translational Medicine

China

Li Guo

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Beijing
China

Jing Yang

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Beijing
China

Chun Wang

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine

Beijing
China

Shuai Jiang

Chinese Academy of Sciences (CAS) - Beijing Institute of Genomics

China

Donghong Yang

Peking University - Department of Respiratory and Critical Care Medicine

China

Guoliang Zhang

Southern University of Science and Technology - National Clinical Research Center for Infectious Diseases

China

Hongru Li

Fujian Provincial Hospital ( email )

Fuzhou
China

Fuhui Chen

Harbin Medical University - Department of Respiratory

China

Yu Xu

Peking University - Department of Respiratory and Critical Care Medicine

China

Mingwei Chen

Xi'an Jiaotong University (XJTU) - Department of Respiratory and Critical Care Medicine ( email )

China

Zhancheng Gao

Peking University - Department of Respiratory and Critical Care Medicine

China

Jian Yang

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Beijing
China

Jie Dong

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Beijing
China

Bo Liu

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens

Beijing
China

Xiannian Zhang

Capital Medical University - Beijing Advanced Innovation Center for Human Brain Protection

China

Weidong Wang

Chinese PLA General Hospital - Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure

Beijing, 100853
China

Kunlun He

Chinese PLA General Hospital - Beijing Key Laboratory for Precision Medicine of Chronic Heart

Beijing, 100853
China

Qi Jin

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens ( email )

Beijing
China

Mingkun Li

Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Genomic and Precision Medicine ( email )

Beijing
China

Jianwei Wang

Chinese Academy of Medical Sciences - NHC Key Laboratory of Systems Biology of Pathogens ( email )

Beijing
China

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