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Characteristics of SARS-CoV-2 Infected Patients with Clinical Outcome During Epidemic Ongoing Outbreak in Wuhan, China

20 Pages Posted: 24 Mar 2020

See all articles by Xiao Min Luo

Xiao Min Luo

Wuhan University - Department of Emergency

Wei Zhou

Wuhan University - Cancer Center

Hongxia Xia

Wuhan University - Department of Emergency

Weize Yang

Wuhan University - Department of Emergency

Xiaojie Yan

Wuhan University - Department of Emergency

Benchao Wang

Wuhan University - Department of Emergency

Tangxi Guo

Wuhan University - Department of Emergency

Lu Ye

Wuhan University - Department of Emergency

Jun Xiong

Wuhan University - Department of Emergency

Zongping Jiang

Wuhan University - Department of Emergency

Yu Liu

Wuhan University - Department of Emergency

Bicheng Zhang

Wuhan University - Cancer Center

More...

Abstract

Background: Since Dec 2019, SARS-CoV-2 has caused about fifty thousand patients and over two thousand deaths in Wuhan, China. We reported characteristics of SARS-CoV-2 infected patients with clinical outcome during epidemic ongoing outbreak in Wuhan.

Methods: Data of COVID-19 patients with clinical outcome in a designated hospital in Wuhan, were retrospectively collected from electronic medical records. Characteristics were compared between patients who died or recovered, and between patients with different disease severity.

Findings: By Feb 25, 2020, 403 patients were enrolled, 100 died and 303 recovered. The patients who died had higher median age, higher proportion of males and chronic diseases than patients who recovered. Duration from illness onset to admission was 9 (7–12) days. Patients with severe or critical illness had more days from onset to admission compared to those with ordinary illness. Lymphopenia, anemia, hypoproteinemia, and abnormal serum sodium were presented in 52·6%, 54·6%, 69·8%, and 21·8% cases, respectively. Patients who died or with severe/critical illness showed increased white blood cell and neutrophil count, increased serum total bilirubin, creatinine, hypersensitive troponin I, D-dimer, procalcitonin, and C-reactive protein, and decreased red blood cell, lymphocyte, platelet count, and serum albumin on admission compared to those who recovered or with ordinary illness.

Interpretation: Multiple homeostasis disturbances were common in patients with severe or critical illness before admission. Early support should be provided, especially for old men with chronic disease, which is vital to restrain disease progression and reduce mortality of COVID-19.

Funding Statement: This study received no funding.

Declaration of Interests: All authors declare that they have no competing interests.

Ethics Approval Statement: This study was approved by the Research Ethics Committee of Renmin Hospital of Wuhan University (approval number: WDRM 2020-K038). Written consent was not required for patients since it was a retrospective, observational study.

Keywords: COVID-2019; SARS-CoV-2; homeostasis disturbance; inflammatory response; early intervention

Suggested Citation

Luo, Xiao Min and Zhou, Wei and Xia, Hongxia and Yang, Weize and Yan, Xiaojie and Wang, Benchao and Guo, Tangxi and Ye, Lu and Xiong, Jun and Jiang, Zongping and Liu, Yu and Zhang, Bicheng, Characteristics of SARS-CoV-2 Infected Patients with Clinical Outcome During Epidemic Ongoing Outbreak in Wuhan, China (3/11/2020). Available at SSRN: https://ssrn.com/abstract=3552812 or http://dx.doi.org/10.2139/ssrn.3552812

Xiao Min Luo (Contact Author)

Wuhan University - Department of Emergency ( email )

Wuhan
China

Wei Zhou

Wuhan University - Cancer Center

China

Hongxia Xia

Wuhan University - Department of Emergency

Wuhan
China

Weize Yang

Wuhan University - Department of Emergency

Wuhan
China

Xiaojie Yan

Wuhan University - Department of Emergency

Wuhan
China

Benchao Wang

Wuhan University - Department of Emergency

Wuhan
China

Tangxi Guo

Wuhan University - Department of Emergency

Wuhan
China

Lu Ye

Wuhan University - Department of Emergency

Wuhan
China

Jun Xiong

Wuhan University - Department of Emergency

Wuhan
China

Zongping Jiang

Wuhan University - Department of Emergency

Wuhan
China

Yu Liu

Wuhan University - Department of Emergency

Wuhan
China

Bicheng Zhang

Wuhan University - Cancer Center ( email )

China

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