Synthesis of Spions to Deliver Drug In-Vitro and to Use As Contrasting Agent

International Journal of Advanced Research in Engineering and Technology (IJARET), 11 (2), 2020, pp 200-208

9 Pages Posted: 7 Apr 2020

See all articles by Antony V Samrot

Antony V Samrot

Department of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, MAHSA University, Jenjarom, Selangor 42610, Malaysia

Karanam Sai Bhavya

Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Chennai, Tamil Nadu, India

Durga Sruthi P

Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiar Nagar, Chennai, Tamil Nadu, India

Raji P

Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Chennai, Tamil Nadu, India

Ponnaiah Paulraj

Department of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, MAHSA University, Jenjarom, Selangor – 42610, Malaysia

Date Written: March 12, 2020

Abstract

SPIONs, an iron oxide with paramagnetic property. It has versatile application in the field of biomedicine and environment. In this present study, SPIONs were synthesized by chemical co-precipitation method, loaded with itraconazole, a drug known to possess antibacterial and antifungal activities, encapsulated with microbial polymer (Polyhydroxybutyrate - PHB). Thus, prepared coreshell SPIONs were used for studying in-vitro delivery of itraconazole. Every stage of the drug coating and PHB encapsulation were studied by Scanning Electron Microscopy. The produced drug loaded nanoparticles were checked for drug release pattern and hemolysis assays. It was found to be releasing drug for long time and less toxic to RBC. The nanoparticles were subjugated as contrasting agent in X-ray imaging, where it showed an enhancement of imaging.

Keywords: SPIONs, drug delivery, imaging

Suggested Citation

V Samrot, Antony and Sai Bhavya, Karanam and Sruthi P, Durga and P, Raji and Paulraj, Ponnaiah, Synthesis of Spions to Deliver Drug In-Vitro and to Use As Contrasting Agent (March 12, 2020). International Journal of Advanced Research in Engineering and Technology (IJARET), 11 (2), 2020, pp 200-208, Available at SSRN: https://ssrn.com/abstract=3553273

Antony V Samrot (Contact Author)

Department of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, MAHSA University, Jenjarom, Selangor 42610, Malaysia ( email )

Jenjarom,
Selangor, 42210
Malaysia

Karanam Sai Bhavya

Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Chennai, Tamil Nadu, India ( email )

Durga Sruthi P

Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiar Nagar, Chennai, Tamil Nadu, India ( email )

Raji P

Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Chennai, Tamil Nadu, India ( email )

Ponnaiah Paulraj

Department of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, MAHSA University, Jenjarom, Selangor – 42610, Malaysia ( email )

Jenjarom,
Selangor, 42210
Malaysia

Here is the Coronavirus
related research on SSRN

Paper statistics

Downloads
16
Abstract Views
103
PlumX Metrics