lancet-header
Preprints with The Lancet is part of SSRN´s First Look, a place where journals and other research experts identify content of interest prior to publication. These preprint papers are not peer-reviewed. Authors have either opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet, or submitted directly via SSRN. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. These papers should not be used for clinical decision making or reporting of research to a lay audience without indicating that this is preliminary research that has not been peer-reviewed. For more information see the Comment published in The Lancet, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com

Clinical Characteristics of Pregnant Women with Coronavirus Disease 2019 in Wuhan, China

25 Pages Posted: 25 Mar 2020

See all articles by Biheng Cheng

Biheng Cheng

Wuhan University - Department of Obstetrics

Tao Jiang

Tongji University - Department of Medical Oncology

Lu Zhang

Wuhan University - Department of Obstetrics

Ruheng Hu

Wuhan University - Department of Obstetrics

Jinhua Tian

Wuhan University - Department of Obstetrics

Yan Jiang

Wuhan University - Department of Obstetrics

Bo Huang

Wuhan University - Department of Obstetrics

Jun Li

Wuhan University - Department of Obstetrics

Min Wei

Wuhan University - Department of Obstetrics

Jing Yang

Wuhan University - Department of Obstetrics

Shengxiang Ren

Tongji University - Department of Medical Oncology

Gaohua Wang

Wuhan University - Department of Psychiatry

More...

Abstract

Background: Coronavirus disease 2019 (COVID-19) has become a pandemic. Despite of the growing number of patients with COVID-19 infection, data on the clinical characteristics of pregnant women is still unknown.

Methods: In this retrospective case-control study, we included childbearing-age women patients with laboratory-confirmed COVID-19 at Renmin Hospital of Wuhan University (Wuhan, China) from January 15 to February 23, 2020. Demographic, clinical, radiological, laboratory, and treatment data were reviewed and analyzed. Clinical characteristics and disease severity of pregnant and non-pregnant patients were compared.

Findings: 111 childbearing-age women with COVID-19 were included, including severe or critical disease in 16 patients (14.4%). Compared with non-pregnant patients (n = 80), pregnant patients (n = 31) were younger (median age, 29.0 vs 33.0 years), less likely to have dyspnea (16.1%] vs 37.5%), asthenia (3.2% vs 33.8%), and symptoms number ≥ 3 (22.6% vs 45.0%), had significantly higher white blood cell count (6.9 vs 4.6 × 10 9 /L), neutrophil count (5.2 vs 2.5 × 10 9 /L), higher percentage of CD3+ cells (76.7% vs 73.7%) and CD8+ cells (32.3% vs 28.4%), and had dramatically lower percentage of lymphocyte (18.2% vs 31.8%), lower CD4+/CD8+ ratio (1.2 vs 1.4), lower level of IgG (9.8 vs 11.9 g/L). Notably, pregnant patients had significantly lower percentage of severe disease (3.2% vs. 18.8%) and substantially higher level of inflammation markers including neutrophil-to-lymphocyte ratio (4.4 vs 1.9) and systematic inflammatory index (812.8 vs 354.7) than non-pregnant patients.

Interpretation: Pregnant patients with COVID-19 had less level of severity together with enhanced inflammatory response and cell immunity when compared with non-pregnant patients.

Funding Statement: This work was supported by the Scientific Research Projects from Health and Family Planning Commission in Hubei Province (grant WJ2017M026 to Dr B. Cheng), Wuhan University School of Medicine (grant TFZZ2018018 to Dr B. Cheng), Wuhan University postdoctoral research project (grant 169557 to Dr B. Cheng), Shanghai Pujiang Talent Plan (grant 2019PJD048 to Dr S. Ren), Shanghai Key disciplines of Respiratory (grant 2017ZZ02012 to Dr S. Ren), and Shanghai Major Diseases Multidisciplinary Cooperation Diagnosis and Treatment Construction Project.

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: This study was approved by the Research Ethics Committee of Renmin Hospital of Wuhan University (approval number: WDRY2020-K076). Considering the urgent need for public health outbreak investigation, written informed consent was waived. All data were anonymously collected and analyzed.

Keywords: COVID-2019; Pregnant Women; Clinical Characteristics; Severity

Suggested Citation

Cheng, Biheng and Jiang, Tao and Zhang, Lu and Hu, Ruheng and Tian, Jinhua and Jiang, Yan and Huang, Bo and Li, Jun and Wei, Min and Yang, Jing and Ren, Shengxiang and Wang, Gaohua, Clinical Characteristics of Pregnant Women with Coronavirus Disease 2019 in Wuhan, China (3/12/2020). Available at SSRN: https://ssrn.com/abstract=3555240 or http://dx.doi.org/10.2139/ssrn.3555240

Biheng Cheng

Wuhan University - Department of Obstetrics

Wuhan
China

Tao Jiang

Tongji University - Department of Medical Oncology

No. 507, Zheng Min Road
Shanghai, Shanghai
China

Lu Zhang

Wuhan University - Department of Obstetrics

Wuhan
China

Ruheng Hu

Wuhan University - Department of Obstetrics

Wuhan
China

Jinhua Tian

Wuhan University - Department of Obstetrics

Wuhan
China

Yan Jiang

Wuhan University - Department of Obstetrics

Wuhan
China

Bo Huang

Wuhan University - Department of Obstetrics

Wuhan
China

Jun Li

Wuhan University - Department of Obstetrics

Wuhan
China

Min Wei

Wuhan University - Department of Obstetrics

Wuhan
China

Jing Yang

Wuhan University - Department of Obstetrics

Wuhan
China

Shengxiang Ren

Tongji University - Department of Medical Oncology

No. 507, Zheng Min Road
Shanghai, Shanghai
China

Gaohua Wang (Contact Author)

Wuhan University - Department of Psychiatry ( email )

Wuhan
China

Click here to go to TheLancet.com

Paper statistics

Abstract Views
807
Downloads
146