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The Variation Analysis of Clinical, Biological and Epidemiological Characteristics Among the COVID-19 Confirmed Patients with Different Clinical Staging

12 Pages Posted: 30 Mar 2020

See all articles by Zhiwei Xu

Zhiwei Xu

Binzhou Medical University - Yantai Affiliated Hospital

Dexi Zhao

Government of the People's Republic of China - Fifth Medical Center

Chaohui Xiao

Government of the People's Republic of China - Fifth Medical Center

Peng Yu

Government of the People's Republic of China - Fifth Medical Center

Peng Zhao

Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital

Guang Yang

Government of the People's Republic of China - Fifth Medical Center

Bolun Zhang

Government of the People's Republic of China - Fifth Medical Center

Jin Yan

Government of the People's Republic of China - Fifth Medical Center

Qing Xi

Government of the People's Republic of China - Fifth Medical Center

Zhaohai Wang

Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital

Enqiang Qin

Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital

More...

Abstract

Background: Since December 2019, Novel coronavirus pneumonia has been reported from Wuhan, China, we try to analysis the clinical, biological and epidemiological characteristics among the COVID-19 confirmed patients, and find the variation of different clinical staging.

Methods: We conducted a retrospective study on all patients with confirmed COVID-19 who were admitted for care at Fifth Medical center of PLA General Hospital in Peking, we used the respiratory or blood samples by RT-PCR or highly homologous with COVID-19 by sequencing of virus genes is positive result was the diagnosis standard for Novel Coronavirus Pneumonia.

Results: 55 patients (23 female and 32 male) clinical, biological and epidemiological characteristic were collected in our study, the age of them ranging from 3 to 85 years with the mean age was 44.93 years (SD=17.86). 34/55 had travelled or lived in Wuhan or Hubei, and 29/55 had contact with confirmed patients, 4 patients had no the travel or contact history. The most confirmed patients had the fever (47/55) and cough (28/55), fever (85.45%), pneumonia (65.45%), and cough (50.91%) were important sign of COVID-19, the time from exposure to morbidity were ranging from 1 to 22 days with mean time was 7.84 (4.78) days. IL-6 (56.85%), Lactic acid (48.89%), CPR (41.82%), and ESR (39.22%) were significant improvement than normal, and CD4 (44.73%), T-LYM (28.21%), B-LYMV (25.71%), NK-LYMV (25.71%), and CD8 (21.05%) had a decrease than normal.

Conclusion: All people are susceptible for COVID-19, most confirmed patients had the travel history to Wuhan or contact history with confirmed patient, poor immunity had a higher risk to get COVID-19 than others, the most common clinical symptoms are fever, cough, and weakness, the mean incubation in our study are 7.84 days, the confirmed patients usually had the IL-6, Lactic acid, CPR, and ESR. Elder and had anamnesis patients had the high risk of deterioration than others, and the clinical staging and complication had highly correlated.

Funding Statement: None.

Declaration of Interests: None.

Ethics Approval Statement: The study was approved by the Fifth Medical center of PLA General Hospital.

Keywords: Clinical characteristic; Biochemical characteristic; epidemiological characteristic; COVID-19; Novel coronavirus pneumonia; 2019-Ncov

Suggested Citation

Xu, Zhiwei and Zhao, Dexi and Xiao, Chaohui and Yu, Peng and Zhao, Peng and Yang, Guang and Zhang, Bolun and Yan, Jin and Xi, Qing and Wang, Zhaohai and Qin, Enqiang, The Variation Analysis of Clinical, Biological and Epidemiological Characteristics Among the COVID-19 Confirmed Patients with Different Clinical Staging (3/14/2020). Available at SSRN: https://ssrn.com/abstract=3556630 or http://dx.doi.org/10.2139/ssrn.3556630

Zhiwei Xu

Binzhou Medical University - Yantai Affiliated Hospital ( email )

No.717 jin bu road
Yantai, Shandong 265200
China

Dexi Zhao

Government of the People's Republic of China - Fifth Medical Center ( email )

China

Chaohui Xiao

Government of the People's Republic of China - Fifth Medical Center ( email )

China

Peng Yu

Government of the People's Republic of China - Fifth Medical Center

China

Peng Zhao

Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital

Beijing, 100039
China

Guang Yang

Government of the People's Republic of China - Fifth Medical Center

China

Bolun Zhang

Government of the People's Republic of China - Fifth Medical Center

China

Jin Yan

Government of the People's Republic of China - Fifth Medical Center

China

Qing Xi

Government of the People's Republic of China - Fifth Medical Center

China

Zhaohai Wang

Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital ( email )

Beijing, 100039
China

Enqiang Qin (Contact Author)

Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital ( email )

Beijing, 100039
China

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