lancet-header
Preprints with The Lancet is part of SSRN´s First Look, a place where journals and other research experts identify content of interest prior to publication. These preprint papers are not peer-reviewed. Authors have either opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet, or submitted directly via SSRN. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. These papers should not be used for clinical decision making or reporting of research to a lay audience without indicating that this is preliminary research that has not been peer-reviewed. For more information see the Comment published in The Lancet, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com

Epidemiological and Clinical Characteristics of COVID-19 Patients in Shiyan City of Hubei Province, China

33 Pages Posted: 31 Mar 2020

See all articles by Long Liu

Long Liu

Hubei University of Medicine - Department of Infectious Diseases

Xu Lei

Hubei University of Medicine - Department of Infectious Diseases

Xiao Xiao

Hubei University of Medicine - Department of Infectious Diseases

Jing Yang

Hubei University of Medicine - Department of Infectious Diseases

Jian Li

Hubei University of Medicine - Department of Infectious Diseases

Manshan Ji

Hubei University of Medicine - Department of Infectious Diseases

Weixing Du

Hubei University of Medicine - Department of Infectious Diseases

Huabing Tan

Hubei University of Medicine - Department of Infectious Diseases

Jianyong Zhu

Hubei University of Medicine - Department of Infectious Diseases

Li Bei

Hubei University of Medicine - Department of Infectious Diseases

Zhixiong Jin

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Clinical Laboratory

Weiyong Liu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Clinical Laboratory

Jianguo Wu

Jinan University - Guangdong Provincial Key Laboratory of Virology; Wuhan University - State Key Laboratory of Virology

Zhixin Liu

Hubei University of Medicine - Department of Infectious Diseases; Wuhan University - State Key Laboratory of Virology

More...

Abstract

Background: The outbreak of the 2019 novel coronavirus (2019-nCoV, also named SARS-CoV-2) has spread from Wuhan to outside of Hubei province and other countries or regions, caused thousands of patients with disease named “Coronavirus Disease 2019 (COVID-19)”, and led to a public health emergency of international concern (PHEIC) declared by World Health Organization (WHO). The person-to-person spread of SARS-CoV-2 was reported among close contacts.

Methods: To investigate the early epidemic of COVID-19, totally 176 confirmed COVID-19 cases in Shiyan city, Hubei province, China were surveyed. Their traces of activities and contacts were tracked and analyzed. Among the 176 confirmed cases, 53 patients were admitted to the Shiyan Renmin Hospital of Hubei University of Medicine. The clinical characteristics on the 53 patients were collected and compared based on the nucleotides and pneumonia in laboratory inspection.

Findings: The early confirmed COVID-19 cases in Hubei province outside Wuhan were emerged by migrate rate-dependent, and the second-generation patients were mainly cluster-onset between family members from Wuhan travelers. Epidemiological investigation indicated that 10.7% (12/112) of local COVID-19 cases were transferred SARS-CoV-2 by asymptomatic infected individuals. Clinical data showed that 47.2% (25/53) of the COVID-19 patients were co-infected with the Meningococcal pneumonia.

Interpretation: It should be paid more attentions to the high incidence of coinfections with M. pneumoniae in the COVID-19 patients. It is necessary to assess the transmissibility of asymptomatic infected individuals and other possibilities for SARS-CoV-2 transmission. The strict intervention measures should be adopted by the public to lower basic reproduction number and stop the spread.

Funding Statement: This work was supported by research grants from the National Natural Science Foundation of China (81902066, 81730061, and 81471942), the Natural Science Foundation of Hubei Provincial Department of Education (Q20192105 and Q20192104), the Hubei Provincial Natural Science Foundation (2018CFB185 and 2018CFB093), Cultivating Project for Young Scholar at Hubei University of Medicine (2017QDJZR08 and 2016QDJZR03), and National Undergraduate Training Program for Innovation and Entrepreneurship (201913249002).

Declaration of Interests: The authors have no conflicts of interest to disclose.

Ethics Approval Statement: This study was conducted in accordance with the Declaration of Helsinki. This study was approved by the Shiyan Renmin Hospital of Hubei University of Medicine institutional review board and the need for informed consent was waived.

Keywords: Asymptomatic infected individuals; Coinfection; COVID-19; Epidemiological and clinical characteristics; Meningococcal pneumonia; SARS-CoV-2 transmission; SARS-CoV-2

Suggested Citation

Liu, Long and Lei, Xu and Xiao, Xiao and Yang, Jing and Li, Jian and Ji, Manshan and Du, Weixing and Tan, Huabing and Zhu, Jianyong and Bei, Li and Jin, Zhixiong and Liu, Weiyong and Wu, Jianguo and Liu, Zhixin, Epidemiological and Clinical Characteristics of COVID-19 Patients in Shiyan City of Hubei Province, China (3/13/2020). Available at SSRN: https://ssrn.com/abstract=3556661 or http://dx.doi.org/10.2139/ssrn.3556661

Long Liu

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Xu Lei

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Xiao Xiao

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Jing Yang

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Jian Li

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Manshan Ji

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Weixing Du

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Huabing Tan

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Jianyong Zhu

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Li Bei

Hubei University of Medicine - Department of Infectious Diseases

Shiyan, 442000
China

Zhixiong Jin

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Clinical Laboratory

1239 Siping Road
Shanghai, 200092
China

Weiyong Liu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Clinical Laboratory

1239 Siping Road
Shanghai, 200092
China

Jianguo Wu (Contact Author)

Jinan University - Guangdong Provincial Key Laboratory of Virology ( email )

Guangzhou, 510632
China

Wuhan University - State Key Laboratory of Virology ( email )

Wuhan, Hubei 430072
China

Zhixin Liu

Hubei University of Medicine - Department of Infectious Diseases ( email )

Shiyan, 442000
China

Wuhan University - State Key Laboratory of Virology ( email )

Wuhan, Hubei 430072
China

Click here to go to TheLancet.com

Paper statistics

Abstract Views
571
Downloads
67