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Association Between Age and Clinical Characteristics and Outcomes of Coronavirus Disease 2019

46 Pages Posted: 31 Mar 2020

See all articles by Yang Liu

Yang Liu

Tongji University - Department of Pulmonary and Critical Care Medicine

Bei Mao

Tongji University - Department of Pulmonary and Critical Care Medicine

Shuo Liang

Tongji University - Department of Pulmonary and Critical Care Medicine

Jia-wei Yang

Tongji University - Department of Pulmonary and Critical Care Medicine

Hai-wen Lu

Tongji University - Department of Pulmonary and Critical Care Medicine

Yan-hua Chai

Tongji University - Department of Pulmonary and Critical Care Medicine

Lan Wang

Tongji University - Department of Pulmonary Circulation Medicine

Li Zhang

Tongji University - Department of Pulmonary and Critical Care Medicine

Qiu-hong Li

Tongji University - Department of Pulmonary and Critical Care Medicine

Lan Zhao

Tongji University - Department of Pulmonary and Critical Care Medicine

Yan He

Tongji University - Department of Pulmonary and Critical Care Medicine

Xiao-long Gu

Shanghai Pudong New Area People's Hospital - Department of Respiratory Medicine

Xiao-bin Ji

Zhoupu Hospital of Pudong New District - Department of Respiratory Medicine

Li Li

Shanghai University of Traditional Chinese Medicine - Department of Respiratory Medicine

Zhi-jun Jie

Fudan University - Department of Respiratory and Critical Care Medicine

Qiang Li

Tongji University - Department of Respiratory and Critical Care Medicine

Xiang-yang Li

Fudan University - Department of Respiratory and Critical Care Medicine

Hong-zhou Lu

Fudan University - Shanghai Public Health Clinical Center

Wen-hong Zhang

Fudan University - Department of Infectious Diseases

Yuan-lin Song

Fudan University - Department of Respiratory and Critical Care Medicine

Jie-ming Qu

Shanghai Jiao Tong University (SJTU) - Department of Respiratory and Critical Care Medicine

Jin-Fu Xu

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai Clinical Treatment Experts Group for COVID-19

More...

Abstract

Background: Systematic assessment of the impact of age on the clinical characteristics and outcomes of coronavirus disease 2019 (COVID -19) is crucial for clinicians worldwide to establish risk stratification of patients.

Methods: Totally 221 COVID-19 patients from the fever clinics of 117 designated hospitals admitted to Shanghai Public Health Center were enrolled. Data on clinical features, exposure history, radiographic and laboratory findings of them were collected. Different cohorts were generated according to the age of the patients, and clinical features and outcomes were compared.

Findings: Difference on the percentage of fever (79·6%) in three groups was not significant. The proportion of bacteria co-infection and antibiotic therapy were higher in patients with age ≥65 years than those in patients younger than 45 years. CURB-65 score of patients was increased successively following the increase of age (p<0·05). Patients older than 45 appeared more bilateral lesions and more lobes affected than those age <45 years (p<0·001). Serological indicators such as Lymphocyte (L), L%, Ca2+, albumin, CD4+T cells showed decrease, while the level of blood urea nitrogen, C-Reactive Protein, lactate dehydrogenase and D-dimer increased following the increasing of the age (p<0·05). The needs of intravenous corticosteroids, heparin therapy and assisted ventilation were higher in those age≥45 years than those age< 45 years. Older patients showed longer time to cure and higher proportion of respiratory failure.

Interpretation: Age significantly determined the clinical features and prognosis of the disease. The prognosis was worse in patients older than 60 years, calling for clinicians to pay more attention to patients on this special age.

Funding Statement: This work was supported by the National Natural Science Fund for Distinguished Young Scholars to JFX (81925001), Shanghai Leading Talent Program (No. 2016036 to JFX) and the Project of the Shanghai Hospital Development Center (16CR3036A to JFX).

Declaration of Interests: All authors declare that they have no competing interests.

Ethics Approval Statement: Written informed consent was waived by the Ethics Commission for public health needs to emerging infectious diseases.

Keywords: COVID-19; Age; Clinical features; Outcomes

Suggested Citation

Liu, Yang and Mao, Bei and Liang, Shuo and Yang, Jia-wei and Lu, Hai-wen and Chai, Yan-hua and Wang, Lan and Zhang, Li and Li, Qiu-hong and Zhao, Lan and He, Yan and Gu, Xiao-long and Ji, Xiao-bin and Li, Li and Jie, Zhi-jun and Li, Qiang and Li, Xiang-yang and Lu, Hong-zhou and Zhang, Wen-hong and Song, Yuan-lin and Qu, Jie-ming and Xu, Jin-Fu and COVID-19, Shanghai Clinical Treatment Experts Group for, Association Between Age and Clinical Characteristics and Outcomes of Coronavirus Disease 2019 (3/14/2020). Available at SSRN: https://ssrn.com/abstract=3556689 or http://dx.doi.org/10.2139/ssrn.3556689

Yang Liu

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Bei Mao

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
China

Shuo Liang

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Jia-wei Yang

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Hai-wen Lu

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Yan-hua Chai

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Lan Wang

Tongji University - Department of Pulmonary Circulation Medicine

China

Li Zhang

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Qiu-hong Li

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Lan Zhao

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Yan He

Tongji University - Department of Pulmonary and Critical Care Medicine

Shanghai, 200433
United States

Xiao-long Gu

Shanghai Pudong New Area People's Hospital - Department of Respiratory Medicine

Shanghai, 201200
China

Xiao-bin Ji

Zhoupu Hospital of Pudong New District - Department of Respiratory Medicine

Shanghai 201318
China

Li Li

Shanghai University of Traditional Chinese Medicine - Department of Respiratory Medicine

Shanghai, 201900
China

Zhi-jun Jie

Fudan University - Department of Respiratory and Critical Care Medicine ( email )

Shanghai
China

Qiang Li

Tongji University - Department of Respiratory and Critical Care Medicine ( email )

Shanghai
China

Xiang-yang Li

Fudan University - Department of Respiratory and Critical Care Medicine

Shanghai, 200040
China

Hong-zhou Lu

Fudan University - Shanghai Public Health Clinical Center

Shanghai
China

Wen-hong Zhang

Fudan University - Department of Infectious Diseases

12 Central Urumqi Road
Shanghai, 200040
China

Yuan-lin Song

Fudan University - Department of Respiratory and Critical Care Medicine

Shanghai, 200032
China

Jie-ming Qu

Shanghai Jiao Tong University (SJTU) - Department of Respiratory and Critical Care Medicine ( email )

China

Jin-Fu Xu (Contact Author)

Tongji University - Department of Pulmonary and Critical Care Medicine ( email )

Shanghai, 200433
United States

No contact information is available for Shanghai Clinical Treatment Experts Group for COVID-19

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