Random Forest Analysis: A New Approach for Classification of Beta Thalassemia
14 Pages Posted: 19 Mar 2020
Date Written: March 19, 2020
Abstract
In recent years, Thalassemia care providers started classifying patients as transfusion-dependent-Thalassemia (TDT) or non-transfusion-dependent-Thalassemia (NTDT) owing to the established role of transfusion therapy in defining the clinical complication profile, although this classification was also based on expert opinion and is limited by reliance on patients’current transfusion status. Starting from a vast set of variables indicating severity phenotype, through the use of both classification and clustering techniques we want to explore the presence of two (TDT vs NTDT) or more clusters, in order to approaching to a new definition for the classification of Beta-Thalassemia in Thalassemia Syndromes (TS).
Keywords: Random forest, Unsupervised classification, Clustering, Thalassemia
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