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Clinical Characteristics and Outcome of 31 Cases with Covid-19 Diagnosed in Haematology Units in Wuhan, China: A Retrospective Cohort Study

44 Pages Posted: 24 Mar 2020

See all articles by Wenjuan He

Wenjuan He

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

Lei Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Institute of Hematology

Li Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Haematology

Guolin Yuan

Hubei University of Arts and Science - Department of Haematology

Yun Fang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

Wenlan Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

Di Wu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

Bo Liang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

Xiaoting Lu

Independent

Yanling Ma

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Respiratory and Critical Care Medicine

Lei Li

Wuhan Jinyintan Hospital

Hongxiang Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Haematology

Zhichao Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

Qiubai Li

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

More...

Abstract

Background: The severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a pandemic, but data about hospital-associated infection are scarce. We aimed to describe epidemical and clinical features and outcome of SARS-CoV-2 pneumonia (COVID-19) diagnosed in haematological units, including patients with haematological disorders (HD) and health professionals.

Methods: In this retrospective study, we enrolled all the hospitalized patients and medical staff, from January 23 to February 14, at three haematology centres (two in Wuhan, the capital of Hubei and centre of the outbreak; one in Xiangyang, another city in Hubei). Hospitalized patients and medical staff diagnosed with COVID-19 were eligible without additional restriction, with medical records reviewed and data collected.

Findings: There were 31 cases with COVID-19 diagnosed in Wuhan cohorts, with no cases in Xiangyang cohort. Of the 136 hospitalized HD patients and 224 medical staff in Wuhan, 15 (11%, HD cases) and 16 (7·1%, non-HD cases) were diagnosed, respectively, and 13 (86·7%) of the 15 HD cases were patients with haematological malignancies. There was a cluster infection related to intensive care unit. Compared to non-HD cases, HD cases showed significantly more fever, cough, and dyspnoea, higher procalcitonin and c-reactive protein levels, and lower lymphocyte, platelet, and haemoglobin levels ( P < ·001). All the severe or critical cases and non-survivors with COVID-19 were HD cases. Rapid progression with a higher incidence (60% vs 0%) of acute respiratory depression syndrome was detected in non-survivors, with a median survival of 12 (range, 6-29) days from symptom onset of COVID-19, as of February 29.

Interpretation: In haematological units, hospitalized HD patients and medical staff are both at high risk of COVID-19 under an outbreak in Wuhan, partially attributing to hospital-associated transmission. The HD patients are characterized by great respiratory, inflammatory and haematological damages and extremely poor prognosis.

Funding: None.

Declaration of Interest: We declare no competing interests.

Ethical Approval: This study was approved by the Medical Ethics Committee of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (20200062).

Suggested Citation

He, Wenjuan and Chen, Lei and Chen, Li and Yuan, Guolin and Fang, Yun and Chen, Wenlan and Wu, Di and Liang, Bo and Lu, Xiaoting and Ma, Yanling and Li, Lei and Wang, Hongxiang and Chen, Zhichao and Li, Qiubai, Clinical Characteristics and Outcome of 31 Cases with Covid-19 Diagnosed in Haematology Units in Wuhan, China: A Retrospective Cohort Study (3/16/2020). Available at SSRN: https://ssrn.com/abstract=3558004 or http://dx.doi.org/10.2139/ssrn.3558004

Wenjuan He

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

1277 Jiefang Avenue
Wuhan, 430022
China

Lei Chen (Contact Author)

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Institute of Hematology

Wuhan
China

Li Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Haematology

Wuhan
China

Guolin Yuan

Hubei University of Arts and Science - Department of Haematology

Xiangyang, 441021
China

Yun Fang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

1277 Jiefang Avenue
Wuhan, 430022
China

Wenlan Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

1277 Jiefang Avenue
Wuhan, 430022
China

Di Wu

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology

1277 Jiefang Avenue
Wuhan, 430022
China

Bo Liang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Radiology

China

Xiaoting Lu

Independent

No Address Available
United States

Yanling Ma

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Respiratory and Critical Care Medicine

Wuhan, 430022
China

Lei Li

Wuhan Jinyintan Hospital

China

Hongxiang Wang

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Haematology ( email )

Wuhan
China

Zhichao Chen

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology ( email )

1277 Jiefang Avenue
Wuhan, 430022
China

Qiubai Li

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Department of Hematology ( email )

1277 Jiefang Avenue
Wuhan, 430022
China

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