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Dopamine-Related Striatal Neurophysiology is Associated with Specialization of Frontostriatal Reward Circuitry Through Adolescence

32 Pages Posted: 9 Apr 2020 Sneak Peek Status: Review Complete

See all articles by Ashley Clare Parr

Ashley Clare Parr

University of Pittsburgh - Department of Psychiatry

Finnegan Calabro

University of Pittsburgh - Department of Psychiatry

Bart Larsen

University of Pittsburgh - Department of Psychiatry

Brenden Tervo-Clemmens

University of Pittsburgh - Department of Psychiatry

Will Foran

University of Pittsburgh - Department of Psychiatry

Valur Olafsson

Northeastern University

Beatriz Luna

University of Pittsburgh - Department of Psychiatry

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Abstract

Characterizing developmental changes in frontostriatal circuitry is critical to our understanding of adolescent development and can clarify neurobiological mechanisms underlying increased reward sensitivity and sensation seeking, and the emergence of psychopathology during this period. However, the role of striatal neurobiology in the development of frontostriatal circuitry through human adolescence remains largely unknown. We combine longitudinal MR-based assessments of striatal tissue-iron as a correlate of dopamine-related neurobiology with functional magnetic resonance imaging indices of resting-state and reward-state connectivity to investigate the contribution of dopaminergic processes to developmental changes in frontostriatal circuitry. Connectivity between the nucleus accumbens and ventral anterior cingulate, subgenual cingulate, and orbitofrontal cortices decreased through adolescence into adulthood. Nucleus accumbens tissue-iron mediated age-related changes and was associated with variability in connectivity. Our results provide evidence that developmental changes in dopamine-related striatal properties contribute to specialization of frontostriatal circuitry, potentially underlying changes in sensation seeking and reward sensitivity into adulthood.

Keywords: Dopamine, tissue iron, functional connectivity, Reward, adolescent development

Suggested Citation

Parr, Ashley Clare and Calabro, Finnegan and Larsen, Bart and Tervo-Clemmens, Brenden and Foran, Will and Olafsson, Valur and Luna, Beatriz, Dopamine-Related Striatal Neurophysiology is Associated with Specialization of Frontostriatal Reward Circuitry Through Adolescence. Available at SSRN: https://ssrn.com/abstract=3565006 or http://dx.doi.org/10.2139/ssrn.3565006
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Ashley Clare Parr (Contact Author)

University of Pittsburgh - Department of Psychiatry ( email )

Pittsburgh, PA 15219
United States

Finnegan Calabro

University of Pittsburgh - Department of Psychiatry ( email )

Pittsburgh, PA 15219
United States

Bart Larsen

University of Pittsburgh - Department of Psychiatry ( email )

Pittsburgh, PA 15219
United States

Brenden Tervo-Clemmens

University of Pittsburgh - Department of Psychiatry ( email )

Pittsburgh, PA 15219
United States

Will Foran

University of Pittsburgh - Department of Psychiatry ( email )

Pittsburgh, PA 15219
United States

Valur Olafsson

Northeastern University ( email )

220 B RP
Boston, MA 02115
United States

Beatriz Luna

University of Pittsburgh - Department of Psychiatry ( email )

Pittsburgh, PA 15219
United States

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