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Incidence of Down's Syndrome by Maternal Age of Asian Population

8 Pages Posted: 24 Jun 2020

See all articles by Song Yi

Song Yi

Department of Clinical Laboratory;Maternal and Child Health Hospital of Hubei Province

Jieping Song

Department of Clinical Laboratory;Maternal and Child Health Hospital of Hubei Province

Feng Liu

Departmentof Research and Development, TopDX Nanjing Ltd

Xu Liu

Department of Clinical Laboratory;Maternal and Child Health Hospital of Hubei Province

Chengcheng Zhang

Department of Clinical Laboratory;Maternal and Child Health Hospital of Hubei Province

Bo Wang

Maternal and Child Health Hospital of Hubei Province - Department of Clinical Laboratory

Zhiqiao Wang

TopDX Nanjing Ltd - Department of Research and Development

Tim Xiaoming Hu

Agency for Science, Technology and Research (A*STAR) - Institute of Molecular and Cell Biology

More...

Abstract

Objectives: To study the incidence of Down's syndrome by maternal age of the Asian population.

Setting and Design: Data on prenatal serum screening between 2008-2017 was obtained from the Maternal and Child Hospital of Hubei Province. Cases were classified into three groups: ≤26-year-old, 27-33-year-old, and ≥34-year-old. The prevalence of Down's Syndrome was calculated for each age and age bracket separately, and the difference between different groups was analyzed with the chi-square test.

Results: The incidence of Down’s syndrome in maternal age of ≤26-year-old, 27-33-year-old, and ≥34-year-old was 0.67 ‰, 0.29 ‰, and 2.07 ‰, respectively. There were significant differences among different age groups (χ 2 = 79.748, P < 0.05).

Conclusion: In the population investigated, the incidence of Down’s syndrome in maternal age over 34 is much higher than that of the 27-33-year-old group, while younger women aged under 26 are also subject to a higher risk.

Funding Statement: This work was supported by Hubei Provincial Health and Family Planning Scientific Research Project [Grant # WJ2018H0137].

Declaration of Interests: The authors have no conflicts of interest relevant to this article.

Ethics Approval Statement: The research was approved by the Ethics Committee of Maternal and Child Health Hospital of Hubei Province. All patient guardians gave informed consent to the study.

Keywords: Down's Syndrome, Incidence, Maternal Age, Asian Population

Suggested Citation

Yi, Song and Song, Jieping and Liu, Feng and Liu, Xu and Zhang, Chengcheng and Wang, Bo and Wang, Zhiqiao and Xiaoming Hu, Tim, Incidence of Down's Syndrome by Maternal Age of Asian Population (March 31, 2020). Available at SSRN: https://ssrn.com/abstract=3566180 or http://dx.doi.org/10.2139/ssrn.3566180

Song Yi

Department of Clinical Laboratory;Maternal and Child Health Hospital of Hubei Province

Jieping Song

Department of Clinical Laboratory;Maternal and Child Health Hospital of Hubei Province

Feng Liu

Departmentof Research and Development, TopDX Nanjing Ltd

Xu Liu

Department of Clinical Laboratory;Maternal and Child Health Hospital of Hubei Province

Chengcheng Zhang

Department of Clinical Laboratory;Maternal and Child Health Hospital of Hubei Province

Bo Wang (Contact Author)

Maternal and Child Health Hospital of Hubei Province - Department of Clinical Laboratory ( email )

Wuhan
China

Zhiqiao Wang

TopDX Nanjing Ltd - Department of Research and Development ( email )

Wuhan
China

Tim Xiaoming Hu

Agency for Science, Technology and Research (A*STAR) - Institute of Molecular and Cell Biology ( email )

61 Biopolis Drive
138673
Singapore

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