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Analysis of Epidemiological and Clinical Characteristics of Children with Mild COVID-19 and Discussion on the Clinical Significance of SARS-CoV-2 Antibody

15 Pages Posted: 9 Apr 2020

See all articles by Min Xie

Min Xie

Central South University - Department of Pediatrics

Jidong Tian

Central South University - Department of Pediatrics

Marady Hun

Central South University - Department of Pediatrics

Jingzheng Shi

Central South University - Xiangya School of Public Health

Chuanhao Jiang

Central South University - Department of Laboratory Medicine

Kui Xiao

Central South University - Department of Pulmonary and Critical Care Medicine

Weihong Zhu

Central South University - Department of Orthopedics

Yang Wang

Central South University - Department of Pathology

Shi Tai

Central South University - Department of Cardiology

Chongqing Tan

Central South University - Department of Pharmacy

Zhongbiao Jiang

Central South University - Department of Radiology

Chuan Wen

Central South University - Department of Pediatrics

Junmei Xu

Central South University - Department of Anesthesiology

More...

Abstract

Background: COVID-19 cases in children are gradually increasing with limited information. Epidemiological and clinical characteristics of children with mild disease in Wuchang Shelter Hospital were analysed.

Methods: Patients (aged ≤18 years) diagnosed with mild COVID-19 in Wuchang Shelter Hospital in Wuhan were included. Demographic, clinical, laboratory, and radiological data during their hospitalisation and isolation period were collected. Retrospective analysis was performed.

Findings: Overall, 1124 patients with mild COVID-19 were admitted, of whom 13 were children (1•16%) and residents of Wuhan with a median age of 16 years (53•8% male). The source of infection was unknown in 30•8% of children. Four patients (30•8%) had abnormal lung computed tomography (CT) findings. Six children (46•2%) had not symptoms with normal CT. During hospitalisation, two SARS-CoV-2 nucleic acid tests were negative shown in 11 patients, and they were discharged from the hospital. Four times SARS-CoV-2 nucleic acid tests of two children (15.4%) were positive and they transferred to another hospital, leading to loss of follow-up. The SARS-CoV-2 IgM and IgG tests were performed at least once in 8 children, 6 of their SARS-CoV-2 IgM were within the normal reference value and the IgG increased. A dynamic increasing trend of SARS-CoV-2 IgG was showed in 2 children; Twice SARS-CoV-2 IgM and IgG tests were within the normal reference values in 2 children. Among the 11 follow-up children, one had positive results for two SARS-CoV-2 nucleic acids tests at isolation.

Interpretation: Children accounted for 1•16 % of mild cases. Some children had uncertain contact history and no clinical symptoms. The etiological diagnosis of children was more important than clinical diagnosis. Disappearance of clinical manifestations of children and the SARS-CoV-2 nucleic acid test with positive result were not parallel. SARS-CoV-2 had long detoxification time, and SARS-CoV-2 cases with positive results appeared again. The production regularity of SARS-CoV-2 IgM and IgG in children and their effect on the body remain unknown.

Funding Statement: None.

Declaration of Interests: None.

Ethics Approval Statement: This case series was approved by the institutional ethics board of the Second Xiangya Hospital of Central South University (No. LYF2020060). All patients agreed that their medical materials could be quoted and published by doctors.

Keywords: COVID-19; SARS-CoV-2; Children; Antibody

Suggested Citation

Xie, Min and Tian, Jidong and Hun, Marady and Shi, Jingzheng and Jiang, Chuanhao and Xiao, Kui and Zhu, Weihong and Wang, Yang and Tai, Shi and Tan, Chongqing and Jiang, Zhongbiao and Wen, Chuan and Xu, Junmei, Analysis of Epidemiological and Clinical Characteristics of Children with Mild COVID-19 and Discussion on the Clinical Significance of SARS-CoV-2 Antibody (3/31/2020). Available at SSRN: https://ssrn.com/abstract=3566189 or http://dx.doi.org/10.2139/ssrn.3566189

Min Xie

Central South University - Department of Pediatrics

No.139 Middle Renmin Road
Changsha, 410011
China

Jidong Tian

Central South University - Department of Pediatrics

No.139 Middle Renmin Road
Changsha, 410011
China

Marady Hun

Central South University - Department of Pediatrics

No.139 Middle Renmin Road
Changsha, 410011
China

Jingzheng Shi

Central South University - Xiangya School of Public Health

Changsha
China

Chuanhao Jiang

Central South University - Department of Laboratory Medicine

Changsha
China

Kui Xiao

Central South University - Department of Pulmonary and Critical Care Medicine

China

Weihong Zhu

Central South University - Department of Orthopedics

Changsha
China

Yang Wang

Central South University - Department of Pathology

Changsha
China

Shi Tai

Central South University - Department of Cardiology

Changsha
China

Chongqing Tan

Central South University - Department of Pharmacy

Hunan Sheng, 410008
China

Zhongbiao Jiang

Central South University - Department of Radiology

Changsha, Hunan 410083
China

Chuan Wen (Contact Author)

Central South University - Department of Pediatrics ( email )

No.139 Middle Renmin Road
Changsha, 410011
China
+86-073185295297 (Phone)
+86073185292103 (Fax)

Junmei Xu

Central South University - Department of Anesthesiology ( email )

Changsha, Huanan Province
China

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