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Application of ECMO Successfully Treated Critically Ill COVID-19 Patients

25 Pages Posted: 20 Apr 2020

See all articles by Ning Zhou

Ning Zhou

Huazhong University of Science and Technology - Division of Cardiology; Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Luyun Wang

Huazhong University of Science and Technology - Division of Cardiology; Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Jiangang Jiang

Huazhong University of Science and Technology - Division of Cardiology; Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Peng Cheng

Huazhong University of Science and Technology - Division of Cardiology

Guanglin Cui

Huazhong University of Science and Technology - Division of Cardiology; Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Feng Wang

Huazhong University of Science and Technology - Division of Cardiology; Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Zhimin Guan

Huazhong University of Science and Technology - Division of Cardiology

Panpan Zhang

Huazhong University of Science and Technology - Division of Cardiology

Shengqing Li

Fudan University - Department of Respiratory Medicine

Dao Wen Wang

Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

More...

Abstract

Coronavirus disease 2019 (COVID-19) has been pandemic and is leading to many deaths due to refractory respiratory failure. Here, we report our experience of treating 5 critically ill patients with COVID-19 using extracorporeal membrane oxygenation (ECMO) from February 18 to March 31, 2020, in the intensive care unit. All the patients survived and recovered. Our data demonstrates that ECMO is an effective method to save the patients with critically ill COVID-19. ECMO should be applied precede the onset of multiple organ dysfunction syndrome-induced by respiratory failure and hypoxemia, instead of a salvage therapy. For patients with the support of both invasive ventilation and ECMO, it’s reasonable to remove endotracheal intubation first if their lung lesions were well relieved. Our experiences also indicated that awake ECMO without invasive ventilation might be a feasible strategy for the patients with critically ill COVID-19.

Funding Statement: This work grant from the National Natural Science Foundation of China (No. 81570261).

Declaration of Interests: None declared.

Ethics Approval Statement: This study was approved by the Ethics Commission of Tongji Hospital. Written informed consent was waived due to the rapid emergence of this infectious disease.

Keywords: COVID-19, novel coronavirus, respiratory failure, ECMO, hypoxemia

Suggested Citation

Zhou, Ning and Wang, Luyun and Jiang, Jiangang and Cheng, Peng and Cui, Guanglin and Wang, Feng and Guan, Zhimin and Zhang, Panpan and Li, Shengqing and Wen Wang, Dao, Application of ECMO Successfully Treated Critically Ill COVID-19 Patients (4/1/2020). Available at SSRN: https://ssrn.com/abstract=3569889 or http://dx.doi.org/10.2139/ssrn.3569889

Ning Zhou

Huazhong University of Science and Technology - Division of Cardiology

1095# Jiefang Ave.
Wuhan, 430030
China

Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders ( email )

Wuhan
China

Luyun Wang

Huazhong University of Science and Technology - Division of Cardiology

1095# Jiefang Ave.
Wuhan, 430030
China

Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Wuhan
China

Jiangang Jiang

Huazhong University of Science and Technology - Division of Cardiology

1095# Jiefang Ave.
Wuhan, 430030
China

Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Wuhan
China

Peng Cheng

Huazhong University of Science and Technology - Division of Cardiology

1095# Jiefang Ave.
Wuhan, 430030
China

Guanglin Cui

Huazhong University of Science and Technology - Division of Cardiology

1095# Jiefang Ave.
Wuhan, 430030
China

Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Wuhan
China

Feng Wang

Huazhong University of Science and Technology - Division of Cardiology

1095# Jiefang Ave.
Wuhan, 430030
China

Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders

Wuhan
China

Zhimin Guan

Huazhong University of Science and Technology - Division of Cardiology

1095# Jiefang Ave.
Wuhan, 430030
China

Panpan Zhang

Huazhong University of Science and Technology - Division of Cardiology

1095# Jiefang Ave.
Wuhan, 430030
China

Shengqing Li

Fudan University - Department of Respiratory Medicine ( email )

Shanghai, 200040
China

Dao Wen Wang (Contact Author)

Huazhong University of Science and Technology - Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders ( email )

Wuhan
China

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