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Iran COVID-19 Immunological Study:  Remarkable Level of Interleukin-6 in Iranian COVID-19 Hospitalized Patients

20 Pages Posted: 20 Apr 2020

See all articles by Abdolrahman Rostamian

Abdolrahman Rostamian

Independent

Tooba Ghazanfari

Shahed University - Immunoregulation Research Center

Jalil Arabkheradmand

Independent

Maryam Edalatifard

Independent

Sara Ghaffarpour

Shahed University - Immunoregulation Research Center

mohammad reza salehi

Tehran University of Medical Sciences

Seyed Reza Raeeskarami

Independent

Maedeh Mahmoodi Aliabadi

Independent

Maryam Rajabnia Chenary

Independent

Ensie Sadat Mirsharif

Shahed University - Immunoregulation Research Center

Davoud Jamali

Independent

Mohammad Reza Sattarian

Independent

Sajjad Hosseinieselki Sari

Independent

Samira Jafarpour

Independent

Reza Najafizadeh

Independent

Mohammad Mehdi Naghizadeh

Independent

More...

Abstract

Background: Researchers have already reported a high level of interleukin (IL)-6 in patients affected by coronavirus disease 2019 (COVID-19). In this study, we investigated the surge of IL-6 level and its association with the critical health factors in these patients.

Methods: The study sample comprised 111 confirmed hospitalized patients with SARS-CoV-2 and 70 healthy volunteer individuals. Routine laboratory examinations, including hematology, biochemistry, and hormone analysis, as well as IL-6 level measurement, were conducted.

Findings: IL-6 levels were significantly high in hospitalized patients compared with healthy individuals (P < 0.001). The IL-6 level was approximately ten-fold of the normal range in 23.7% of the patients and more than 50% of them signify IL-6 over three-fold of normal range. The levels of BS, LDL, VLDL, ALP, TSH, CRP, platelets, neutrophils, and monocytes were significantly different between patients with diverse levels of IL-6. The values of triglyceride, LDL, VLDL, red blood cells and platelets showed an indirect linear trend and the levels of lactate dehydrogenase, serum glutamic oxaloacetic transaminase, creatine phosphokinase, dehydroepiandrosterone sulfate, and CRP demonstrated a direct linear trend with elevating rate of IL-6. Furthermore, IL-6 levels had a significant and direct correlation with troponin I, CRP, ferritin and pro-calcitonin while it had a significant and indirect correlation with VLDL.Interpretation: A hazardous level of IL-6 probably threatening the critical health factors and has a crucial role in immune-mediated acute lung injury in CIOVID-19 patients.

Funding Statement: Immunoregulation Research Center of Shahed University Ministry of Health, Treatment and Medical Training of Iran.

Declaration of Interests: The authors declare no conflicting of interests.

Ethics Approval Statement: The study was approved by the National Ethics Committee on Research in Medical Sciences affiliated to the Iranian Ministry of Health (Ethical Code: IR.NIMAD.REC.1398.411).

Keywords: COVID-19, SARS-Cov-2, Interleukin 6, Inflammatory mediator

Suggested Citation

Rostamian, Abdolrahman and Ghazanfari, Tooba and Arabkheradmand, Jalil and Edalatifard, Maryam and Ghaffarpour, Sara and salehi, mohammad reza and Raeeskarami, Seyed Reza and Aliabadi, Maedeh Mahmoodi and Chenary, Maryam Rajabnia and Mirsharif, Ensie Sadat and Jamali, Davoud and Sattarian, Mohammad Reza and Sari, Sajjad Hosseinieselki and Jafarpour, Samira and Najafizadeh, Reza and Naghizadeh, Mohammad Mehdi, Iran COVID-19 Immunological Study:  Remarkable Level of Interleukin-6 in Iranian COVID-19 Hospitalized Patients (4/4/2020). Available at SSRN: https://ssrn.com/abstract=3571554 or http://dx.doi.org/10.2139/ssrn.3571554

Abdolrahman Rostamian

Independent

Tooba Ghazanfari (Contact Author)

Shahed University - Immunoregulation Research Center ( email )

Tehran
Iran

Jalil Arabkheradmand

Independent

Maryam Edalatifard

Independent

Sara Ghaffarpour

Shahed University - Immunoregulation Research Center

Tehran
Iran

Mohammad reza Salehi

Tehran University of Medical Sciences

Ensie Sadat Mirsharif

Shahed University - Immunoregulation Research Center

Tehran
Iran

Davoud Jamali

Independent

Samira Jafarpour

Independent ( email )

Reza Najafizadeh

Independent

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