Characterization and Antimicrobial Activity of New Cobalt-Nickel-Copper (Ii) Complexes with Benzoin and 3-Amino Benzoic Acid
44 Pages Posted: 13 Apr 2020
Condensation of Benzoin and 3-Amino Benzoic acid yields a novel Schiff base ligand i.e. 3-(2-hydroxy-1,2-diphenylethylideneamino) benzoic acid of type HL. Also, we synthesized the [C 42 H 32 N 2 O 6 Co.2H 2 O], Ni(II) [C 42 H 32 N 2 O 6 Ni.2H 2 O] and Cu(II) [C 42 H 32 N 2 O 6 Cu.2H 2 O] metal complexes. The characterization study of the ligand and metal complexes were carried out by elemental analysis, UV-visible, IR, 1 H NMR spectroscopy, thermal studies and magnetic susceptibility measurement. On the basis of electronic spectral data and magnetic susceptibility measurement the octahedral geometry has been proposed for Co(II), Ni(II) and Cu(II) complexes. The X-ray diffraction study reveals that ligand and all the complexes are crystalline in nature and also possess orthorhombic structure. In vitro antibacterial and antifungal activities assay were performed for the ligand and metal(II) complexes. The micro-organisms Staphylococcus aureus and Pseudomonas aeruginosa and the fungi Candida albicans and Aspergillus Niger were used. Our findings are very promising in the field of clinical research as the highest antimicrobial and antifungal activity is observed for copper complexes.
Keywords: 3-Amino benzoic acid, Schiff base, Antifungal and Antibacterial activity, Transition metal complexes.
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