Modelling Approaches Towards Designing a Putative Autotransmutable Sequence Targeting Spike (S) Glycoprotein of SARS-CoV-2
45 Pages Posted: 30 Apr 2020
Date Written: April 24, 2020
The goal of this paper is to design a putative transmutable sequence from the oligopeptides derived from the spike protein coding sequence of SARS-CoV-2. The purpose for such a sequence is that, the sequence must be unique and be capable of identifying and predicting mutations within the coronavirus genome. By designing a Spike-protein site-specific probe, a novel delivery vehicle could be developed to deliver molecules which would disrupt the structure of the sequence at multiple locations. The autotransmutable sequence can be employed as a vehicle for delivery of Spike protein specific RNA interference molecules that would disrupt and induce strand breakage at different sites of the sequence rendering it non-functional. By applying the knowledge from prior and ongoing research on SARS-CoV-2 strains, we attempt to design such a putative novel therapeutic manoeuvre that could act as a vaccine molecule.
Note: Funding: None.
Conflict of Interest: None declared.
Keywords: Auto-transmutable sequence, CoVID-19, Spike (S) surface glycoprotein, RBD, mutation, SARS-CoV-2, vaccine.
JEL Classification: I10
Suggested Citation: Suggested Citation