Navel Orange Peel Hydroethanolic Extract, Naringin and Naringenin Have Anti-Diabetic Potentials in Type 2 Diabetic Rats

DOI:10.1016/j.biopha.2017.07.094

Posted: 10 Jul 2020

See all articles by Mohammed Abdel-Gabbar

Mohammed Abdel-Gabbar

Faculty of Science, Beni-Suef University; Faculty of Medicine, Zawia University

Date Written: October 1, 2017

Abstract

The therapy of Type 2 Diabetes Mellitus (T2DM) stays a challenging issue. During the last decade, there has been an interest in the expansion of anti-diabetic drugs especially those of natural sources. Thus, the aim of this study was to assess the anti-hyperglycemic and the anti-hyperlipidemic effects as well as the anti-oxidant activities of navel orange hydroethanolic extract and its constituting flavonoids naringin and naringenin on nicotineamide (NA)/streptozotocin (STZ)-induced type 2 diabetic rats. To induce T2DM, 16 h-fasted rats were intraperitoneally injected with STZ at dose of 50 mg/kg body weight (b. w.), 15 min after the intraperitoneal administration of NA (120 mg/kg b. w.). The NA/STZ-induced type 2 diabetic rats were orally treated with navel orange peel hydroethanolic extract, naringin and narengenin at dose level of 100 mg/kg b. w./day for 4 weeks. The treatments with navel orange peel.

Suggested Citation

Abdel-Gabbar, Mohammed, Navel Orange Peel Hydroethanolic Extract, Naringin and Naringenin Have Anti-Diabetic Potentials in Type 2 Diabetic Rats (October 1, 2017). DOI:10.1016/j.biopha.2017.07.094, Available at SSRN: https://ssrn.com/abstract=3587633

Mohammed Abdel-Gabbar (Contact Author)

Faculty of Science, Beni-Suef University ( email )

Salah Salem Ave.,
Beni-Suef
Egypt

Faculty of Medicine, Zawia University ( email )

Ez Zawia
Libya

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