Antiallergic Activity of Curcumin

Abstract

Curcumin is the major and active biological compound of C. longa. Curcumin suppress the mast cell degranulation and release of histamine as well as curcumin act as immunomodulatory agent by activating T-cell and other mediators. Curcumin can suppress expression of CD80, CD86 and class-II antigens by dendritic cells and blocks the release of inflammatory cytokines like IL1β, IL6 and TNFα from LPS-stimulated dendritic cells .After reviewed we seen that curcumin shows Antiallergic activity by different mechanisms and it also shows wide therapeutic range such as Antiallergic, antiviral (Anti-hiv) , Antidiabetic ,Antimicrobial etc. Its provides wide area for the research and development in Pharmaceutical science.

Keywords: Curcumin, Curcuma longa, Antiallergic activity, Mast cell, Immunomodulatory