Lopinavir as a Potential Inhibitor for SARS-CoV-2 Target Protein: A Molecular Docking Study

8 Pages Posted: 18 May 2020

See all articles by Viquar Sameer Shaikh

Viquar Sameer Shaikh

Nowrosjee Wadia College

Yaseen Shaikh

Abeda Inamdar Senior College

Khursheed Ahmed

Abeda Inamdar Senior College

Date Written: May 9, 2020

Abstract

COVID-19 has been the reason for the pandemic, which is induced by the SARS-CoV-2. Potential drugs are being used for its cure, but there's no specific drug for it. To get a specific drug, many drug designing strategies are being used in which molecular docking plays a vital role in computer-assisted drug designing. In this research, we've tested the molecular docking of Lopinavir (LV) on the Receptor Binding Spike proteins of SARS-CoV-2. We’ve generated the ADMET properties consistent with predicted ADMET parameters supported Lipinski’s rule with the aid of the Datawarrior software version 5.2.1.

Note:

Funding:The authors are thankful to Abeda Inamdar College, Pune-411001 for their support. We are also thankful to Innovative informatics Technologies, Miyapur Hyderabad, India for their help in the analysis of docking studies and physical properties.

Declaration of Interest: The authors declare that they have no conflict of interest.

Ethical Approval: This chapter does not contain any studies with human participants or animals performed by any of the authors.

Keywords: SARS-CoV-2, COVID-19, Spike protein, Molecular Docking, Lopinavir

Suggested Citation

Shaikh, Viquar Sameer and Shaikh, Yaseen and Ahmed, Khursheed, Lopinavir as a Potential Inhibitor for SARS-CoV-2 Target Protein: A Molecular Docking Study (May 9, 2020). Available at SSRN: https://ssrn.com/abstract=3596820 or http://dx.doi.org/10.2139/ssrn.3596820

Viquar Sameer Shaikh (Contact Author)

Nowrosjee Wadia College ( email )

Camp
Pune, MA 411001
India

Yaseen Shaikh

Abeda Inamdar Senior College ( email )

Dept. Of Chemistry,Abeda Inamdar Senior College
AISC,Azam Campus,Camp,Pune-411001
Pune, MA Pune 411001
India

Khursheed Ahmed

Abeda Inamdar Senior College ( email )

Dept. Of Chemistry,Abeda Inamdar Senior College
AISC,Azam Campus,Camp,Pune-411001
Pune, MA Pune 411001
India

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