si-RNA-Based Design of an Autotransmutable Sequence As a Therapeutic Modality against Sars-Cov-2
36 Pages Posted: 21 May 2020
Date Written: May 18, 2020
In this paper, we have designed an autotransmutable sequence based on the functional mechanism of siRNA for targeting and silencing/disrupting the gene encoding the Spike (S) protein of SARS-COV-2. We have employed a unique method of restriction digestion-based mechanism to derive several putative oligopeptides which have been utilized to create the novel autotransmutable sequence. The mechanism for targeting the gene of SARS-COV-2 is based on the principles of employing RNA interference technology. This is a computational theoretical approach towards design of a novel therapeutic modality to combat COVID-19 Pandemic and an effort to design a novel approach to design putative elements of therapeutic value.
Note: Funding: None.
Conflict of Interest: None so declared.
Keywords: Autotransmutable sequence, COVID-19, SARS-CoV-2, Spike (S) surface glycoprotein, siRNA, promoter, RBD, transcription repressor
JEL Classification: I10
Suggested Citation: Suggested Citation