si-RNA-Based Design of an Autotransmutable Sequence As a Therapeutic Modality against Sars-Cov-2

36 Pages Posted: 21 May 2020

See all articles by Sidharta Chatterjee

Sidharta Chatterjee

Andhra University, Department of Social Work

Date Written: May 18, 2020

Abstract

In this paper, we have designed an autotransmutable sequence based on the functional mechanism of siRNA for targeting and silencing/disrupting the gene encoding the Spike (S) protein of SARS-COV-2. We have employed a unique method of restriction digestion-based mechanism to derive several putative oligopeptides which have been utilized to create the novel autotransmutable sequence. The mechanism for targeting the gene of SARS-COV-2 is based on the principles of employing RNA interference technology. This is a computational theoretical approach towards design of a novel therapeutic modality to combat COVID-19 Pandemic and an effort to design a novel approach to design putative elements of therapeutic value.

Note: Funding: None.

Conflict of Interest: None so declared.

Keywords: Autotransmutable sequence, COVID-19, SARS-CoV-2, Spike (S) surface glycoprotein, siRNA, promoter, RBD, transcription repressor

JEL Classification: I10

Suggested Citation

Chatterjee, Sidharta, si-RNA-Based Design of an Autotransmutable Sequence As a Therapeutic Modality against Sars-Cov-2 (May 18, 2020). Available at SSRN: https://ssrn.com/abstract=3604144 or http://dx.doi.org/10.2139/ssrn.3604144

Sidharta Chatterjee (Contact Author)

Andhra University, Department of Social Work ( email )

Andhra University
Waltair
Visakhapatnam, Andhra Pradesh
India

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