A Review on How Neutrophils Are Related With Cancer Metastasis
18 Pages Posted: 26 May 2020
Date Written: May 19, 2020
Neutrophils that are mostly related to our body immunity and inflammatory responses are now considered to be an important player in contrast to tumor progression. Along with many controversies, there is much clear evidence that shows neutrophils promote the metastasis process via different modes of actions in a different time frame concerning the advancement of cancer. Not only impacting cell proliferation but also they are found to be helping tumor cells in many events like- angiogenesis, immune escape, invasion, and finally it leads to cancer metastasis. Tumor micro-environment, key players of cancer growth and progression are also affected by mostly neutrophils and it’s secretory. Tumor associated neutrophils (TANs), having certainly different characteristics and expressions, are found high in number around the tumor site and often in pre-metastatic niches. Increased number of premature neutrophils and more neutrophil-extracellular-traps (NETs) formation is associated with a high degree of metastasis in cancer is observed. As neutrophils has potential role in cancer, more research are warranted in this field to fully understood the overall role of this immune cells and it will helps to open a new way to target neutrophils in therapeutic implications for better cancer treatment. In this article we gather currents data of neutrophils, types of neutrophils and its role in cancer and discuss therapeutics strategy.
Keywords: Neutrophils, Metastasis, Plasticity of Neutrophils, TANs, NETs, Cancer Treatments
Suggested Citation: Suggested Citation