Two New Copper(Ii) Binuclear Complexes with Azo Functionalized 2-[(E)-(Pyridine-2yl-Hydrazono)Methyl]Phenol: Characterization, Molecular Structures, Quantum Chemical Calculations, Cryomagnetic Properties and Catalytic Activity

31 Pages Posted: 20 May 2020

See all articles by Prof. R. N. Patel

Prof. R. N. Patel

Awadhesh Pratap Singh University

Satish Kumar Patel

Awadhesh Pratap Singh University

Dinesh Kumhar

affiliation not provided to SSRN

Nirmala Patel

affiliation not provided to SSRN

Abhay Kumar Pate

affiliation not provided to SSRN

R. N. Jadeja

affiliation not provided to SSRN

Neetu Patel

affiliation not provided to SSRN

Ray J. Butcher

Howard University

Miguel Cortijo,

Universidad Complutense de Madrid (UCM)

santiago herrero

affiliation not provided to SSRN

Abstract

The Schiff base is synthesized by the reaction of 2-hydrazinopyridine and salicylaldehyde. The copper(II) binuclear complexes [Cu 2 (µ 2 -ClO 4 )(L) 2 (H 2 O) 2 ](ClO 4 )·H 2 O (1) and [Cu 2 (µ 2 -pyrazine)(L) 2 ](ClO 4 ) 2 (2) with 2-[(E)-(pyridine-2yl-hydrazono)methyl]phenol (HL), were synthesized and characterized using various physicochemical techniques. The molecular structures of both binuclear complexes were evaluated by single-crystal X-ray analysis. Analysis of the supramolecular synthons and their effect on crystal packing is conferred in the context of crystal engineering. The electron paramagnetic spectra are reported as well. The electrochemical behavior of both complexes was explored using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The electronic and spectral properties are described by quantum chemical calculations (TD and DFT).The cryomagnetic investigation (2-300 K) reveal antiferromagnetic exchange coupling between two copper(II) centres of different strength: J CuCu = -21.6 and J CuCu = -6.8 cm -1 for  1 and 2 , respectively. The strong antiferromagnetic coupling between the copper centers found in 1 could be explained not only by magnetic exchange through hydrogen bonds but also through the π-π stacking of the Schiff base ligands. Both binuclear complexes exhibit catalytic activity toward the dismutation of superoxide anion at physiological pH. Although the activity in both complexes is lower than the native enzyme, they have potential as antioxidant SOD model for pharmaceutical applications.

Keywords: Copper(II) complexes, Crystal structure, Biological activity, Quantum chemical calculations, Superoxide dismutase

Suggested Citation

Patel, Prof. R. N. and Patel, Satish Kumar and Kumhar, Dinesh and Patel, Nirmala and Pate, Abhay Kumar and Jadeja, R. N. and Patel, Neetu and Butcher, Ray J. and Cortijo,, Miguel and herrero, santiago, Two New Copper(Ii) Binuclear Complexes with Azo Functionalized 2-[(E)-(Pyridine-2yl-Hydrazono)Methyl]Phenol: Characterization, Molecular Structures, Quantum Chemical Calculations, Cryomagnetic Properties and Catalytic Activity. Available at SSRN: https://ssrn.com/abstract=3606194

Prof. R. N. Patel

Awadhesh Pratap Singh University ( email )

Rewa
India

Satish Kumar Patel (Contact Author)

Awadhesh Pratap Singh University ( email )

Rewa
India

Dinesh Kumhar

affiliation not provided to SSRN

No Address Available

Nirmala Patel

affiliation not provided to SSRN

No Address Available

Abhay Kumar Pate

affiliation not provided to SSRN

No Address Available

R. N. Jadeja

affiliation not provided to SSRN

No Address Available

Neetu Patel

affiliation not provided to SSRN

No Address Available

Ray J. Butcher

Howard University

2400 Sixth Street, NW
Washington, DC 20059
United States

Miguel Cortijo,

Universidad Complutense de Madrid (UCM) ( email )

Carretera de Humera s/n
Madrid, Madrid 28223
Spain

Santiago Herrero

affiliation not provided to SSRN

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