Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of (Hetero)Arenes Using Trifluoroacetic and Related Carboxylic Acids
181 Pages Posted: 10 Jun 2020 Sneak Peek Status: Review CompleteMore...
A mild and practical method has been achieved that allows for the direct C–H trifluoromethylation, perfuoroalkylation and chlorodifluoromethylation of (hetero)arenes using inexpensive, abundant trifluoroacetic acid and the related carboxylic acids. A diverse array of arenes and heteroarenes were successfully transformed into valued fluoroalkylated compounds. The combination of photoredox catalysis and a diaryl sulfoxide provides a platform for the facile generation of fluoroalkyl radicals from the corresponding fluoroalkyl carboxylic acids under mild conditions.
Keywords: photoredox catalysis, trifluoromethylation, perfluoroalkylation, trifluoroacetic acid, arenes
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