Rose and In-vitro Inhibition of SARS-CoV-2 spike: ACE-2 Interaction

10 Pages Posted: 16 Jun 2020 Last revised: 18 Nov 2020

See all articles by Mark Christopher Arokiaraj

Mark Christopher Arokiaraj

Pondicherry Institute of Medical Sciences - Cardiology

Eric Menesson

Tebu Bio

Date Written: May 28, 2020

Abstract

The study was performed to evaluate the novel potentials of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro. ACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was seen in a dose-dependent sequence. The 50% inhibitory concentration was observed at 0.75 percent v/v of the rose extract, and the 90% inhibition was seen at about 1.8 percent v/v. Steam inhalation or nebulization could be simple methods of delivering rose extract to the lower respiratory tract and pulmonary tissues. There is a potential for the rose extract to inhibit SARS-CoV-2 and ACE2 receptor inhibition in-vitro, which could have beneficial effects in Covid-19 treatment. Further tests need to be performed to study the therapeutic benefits in vivo.

Note: Funding: None.

Conflict of Interest: None.

Ethical Approval: Not applicable.

Keywords: SARS-CoV-2 Spike protein: ACE2 inhibition, Rose extract, COVID-19

JEL Classification: I, E

Suggested Citation

Arokiaraj, Mark Christopher and Menesson, Eric, Rose and In-vitro Inhibition of SARS-CoV-2 spike: ACE-2 Interaction (May 28, 2020). Available at SSRN: https://ssrn.com/abstract=3612898 or http://dx.doi.org/10.2139/ssrn.3612898

Mark Christopher Arokiaraj (Contact Author)

Pondicherry Institute of Medical Sciences - Cardiology ( email )

605014
India

Eric Menesson

Tebu Bio

France

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