Furin Protease: From SARS CoV‐2 to Anthrax, Diabetes and Hypertension

Fitzgerald K. Furin protease: From SARS CoV-2 to anthrax, diabetes, and hypertension. Perm J 2020;24:20.187. DOI: https://doi.org/10.7812/TPP/20.187.

6 Pages Posted: 2 Jun 2020 Last revised: 25 Sep 2020

See all articles by Kara Fitzgerald

Kara Fitzgerald

Institute for Functional Medicine

Date Written: May 28, 2020

Abstract

Furin is a protease that is ubiquitous in mammalian metabolism. One of the innovations that make SARS-CoV-2 more infectious than its ancestor viruses is addition of a furin cleavage site. Conditions associated with elevated furin, including diabetes, obesity and hypertension, overlap significantly with vulnerability to the severe form of COVID-19. We suggest that diet and lifestyle modifications that reduce the associated comorbidities may prevent the development of severe COVID-19 by, in part, lowering circulating furin. Likewise, natural and pharmaceutical inhibitors of furin may be candidate prophylactic interventions, or if used early in the COVID-19, may prevent the development of critical symptoms.

Note: Funding: The author declares that the manuscript was written without funding and in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Declaration of Interest: None to declare

Keywords: furin, furin protease, furin cleavage complex, SARS-CoV-2

Suggested Citation

Fitzgerald, Kara, Furin Protease: From SARS CoV‐2 to Anthrax, Diabetes and Hypertension (May 28, 2020). Fitzgerald K. Furin protease: From SARS CoV-2 to anthrax, diabetes, and hypertension. Perm J 2020;24:20.187. DOI: https://doi.org/10.7812/TPP/20.187., Available at SSRN: https://ssrn.com/abstract=3612934 or http://dx.doi.org/10.2139/ssrn.3612934

Kara Fitzgerald (Contact Author)

Institute for Functional Medicine ( email )

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Federal Way, WA 98003
United States
98003 (Fax)

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