Furin Protease: From SARS CoV‐2 to Anthrax, Diabetes and Hypertension
Fitzgerald K. Furin protease: From SARS CoV-2 to anthrax, diabetes, and hypertension. Perm J 2020;24:20.187. DOI: https://doi.org/10.7812/TPP/20.187.
6 Pages Posted: 2 Jun 2020 Last revised: 25 Sep 2020
Date Written: May 28, 2020
Furin is a protease that is ubiquitous in mammalian metabolism. One of the innovations that make SARS-CoV-2 more infectious than its ancestor viruses is addition of a furin cleavage site. Conditions associated with elevated furin, including diabetes, obesity and hypertension, overlap significantly with vulnerability to the severe form of COVID-19. We suggest that diet and lifestyle modifications that reduce the associated comorbidities may prevent the development of severe COVID-19 by, in part, lowering circulating furin. Likewise, natural and pharmaceutical inhibitors of furin may be candidate prophylactic interventions, or if used early in the COVID-19, may prevent the development of critical symptoms.
Note: Funding: The author declares that the manuscript was written without funding
and in the absence of any commercial or financial relationships that
could be construed as a potential conflict of interest.
Declaration of Interest: None to declare
Keywords: furin, furin protease, furin cleavage complex, SARS-CoV-2
Suggested Citation: Suggested Citation