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Asthma Among Hospitalized Patients with COVID-19 and Related Outcomes

27 Pages Posted: 16 Jul 2020

See all articles by Stephanie Lovinsky-Desir

Stephanie Lovinsky-Desir

Columbia University - Division of Pediatric Pulmonology

Deepti R. Deshpande

Columbia University Irving Medical Center - Division of Allergy, Immunology and Rheumatology

Aliva De

Columbia University - Division of Pediatric Pulmonology

Laurie Murray

New York Presbyterian - Morgan Stanley Children’s Hospital of New York - Department of Pediatrics

Jeanette A. Stingone

Mount Sinai Health System - Icahn School of Medicine

Angela Chan

Columbia University - Division of Allergy, Immunology and Rheumatology

Neha Patel

Columbia University - Division of Pediatric Pulmonology

Nooralam Rai

Columbia University - Division of Pediatric Pulmonology

Emily DiMango

Columbia University - Division of Pulmonary, Allergy and Critical Care Medicine

Joshua Milner

Columbia University - Division of Allergy, Immunology and Rheumatology

Meyer Kattan

Columbia University - Division of Pediatric Pulmonology

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Abstract

Background: Several underlying conditions have been associated with severe SARS-CoV2 illness, but the role of asthma as a comorbidity is not completely understood. Given the high prevalence of asthma in the New York City area, we investigated hospitalized patients with severe COVID-19 disease and the impact of asthma on disease outcomes.

Methods: Electronic heath records were reviewed for 1,298 sequential patients age < 65 years without chronic obstructive pulmonary disease (COPD) who were admitted to our hospital system with a confirmed positive SARS-CoV-2 test.

Results: The overall prevalence of asthma among all hospitalized patients with COVI-19 was 12·6%, yet a higher prevalence (23·6%) was observed in the subset 55 patients <21 years of age. There was no significant difference in hospital length of stay, need for intubation, length of intubation, tracheostomy tube placement, hospital readmission or mortality between asthmatic vs. non-asthmatic patients. Observations between asthmatic and non-asthmatic patients were similar when stratified by obesity, other comorbid conditions (i.e. hypertension, hyperlipidemia, and diabetes), use of controller asthma medication and absolute eosinophil count.

Conclusions: Among hospitalized patients < 65 years with severe COVID-19, asthma diagnosis was not associated with worse outcomes, regardless of age, obesity, or other high-risk comorbidities. Future population based studies are needed to investigate the risk of developing COVID-19 among patients with asthma once universal testing becomes readily available.

Funding Statement: K01 HL140216, Robert Wood Johnson Foundation – Amos Medical Faculty Development Award Program.

Declaration of Interests: The authors have no financial relationships relevant to this article to disclose. Deepti R. Deshpande: Spouse employed by Bristol Myers Squibb.

Ethics Approval Statement: The study was approved by the institutional review board of Columbia University Irving Medical Center under expedited review with a waiver of consent.

Keywords: SARS-CoV2; coronavirus; New York City; respiratory disease

Suggested Citation

Lovinsky-Desir, Stephanie and Deshpande, Deepti R. and De, Aliva and Murray, Laurie and Stingone, Jeanette A. and Chan, Angela and Patel, Neha and Rai, Nooralam and DiMango, Emily and Milner, Joshua and Kattan, Meyer, Asthma Among Hospitalized Patients with COVID-19 and Related Outcomes (5/27/2020). Available at SSRN: https://ssrn.com/abstract=3616172 or http://dx.doi.org/10.2139/ssrn.3616172

Stephanie Lovinsky-Desir (Contact Author)

Columbia University - Division of Pediatric Pulmonology ( email )

3959 Broadway, CHC-701
New York, NY
United States
212-305-5122 (Phone)
718-305-6103 (Fax)

Deepti R. Deshpande

Columbia University Irving Medical Center - Division of Allergy, Immunology and Rheumatology

630 West 168th Street
New York, NY 10032
United States

Aliva De

Columbia University - Division of Pediatric Pulmonology

New York, NY
United States

Laurie Murray

New York Presbyterian - Morgan Stanley Children’s Hospital of New York - Department of Pediatrics

New York, NY
United States

Jeanette A. Stingone

Mount Sinai Health System - Icahn School of Medicine ( email )

1 Gustave L. Levy Pl
New York, NY 10029
United States

Angela Chan

Columbia University - Division of Allergy, Immunology and Rheumatology

630 West 168th Street
New York, NY 10032
United States

Neha Patel

Columbia University - Division of Pediatric Pulmonology

New York, NY
United States

Nooralam Rai

Columbia University - Division of Pediatric Pulmonology

New York, NY
United States

Emily DiMango

Columbia University - Division of Pulmonary, Allergy and Critical Care Medicine

630 West 168th Street
New York, NY 10032
United States

Joshua Milner

Columbia University - Division of Allergy, Immunology and Rheumatology

630 West 168th Street
New York, NY 10032
United States

Meyer Kattan

Columbia University - Division of Pediatric Pulmonology

New York, NY
United States

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