The potential effectiveness of acetazolamide in the prevention of acute kidney injury in COVID-19: A hypothesis

Parham Habibzadeh, Mohammad Mofatteh, Saeid Ghavami, Jamshid Roozbeh, The potential effectiveness of acetazolamide in the prevention of acute kidney injury in COVID-19: A hypothesis, European Journal of Pharmacology, Volume 888, 2020, 173487, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2020.17

3 Pages Posted: 15 Jun 2020 Last revised: 21 Aug 2020

See all articles by Parham Habibzadeh

Parham Habibzadeh

Shiraz University of Medical Sciences

Mohammad Mofatteh

University of Oxford

Saeid Ghavami

University of Manitoba

Jamshid Roozbeh

Shiraz University of Medical Sciences

Date Written: June 4, 2020

Abstract

Acute kidney injury (AKI) is an important complication of COVID-19 encompassing a wide range of presentations. SARS-CoV-2 is proposed to cause AKI in the patients through various mechanisms. We are, nevertheless, far from a comprehensive understanding of the underlying pathophysiological mechanisms of the kidney injury in this infection. AKI has been shown to be a marker of disease severity and also a negative prognostic factor for survival. Unfortunately, no effective preventive strategy to decrease the risk of kidney damage in these patients has yet been identified. In this hypothesis, we highlight the potential protective effects of acetazolamide, a carbonic anhydrase inhibitor, in preventing the proximal tubular damage caused by the virus through disrupting the virus-endosome fusion and also interfering with the lysosomal proteases. Our proposed mechanisms could pave the way for further in vitro studies and subsequent clinical trials.

Note: Declaration of Interest: None to declare.

Funding: None to declare

Keywords: COVID-19, SARS-CoV-2, Acute Kidney Injury, Acetazolamide, Carbonic Anhydrases

Suggested Citation

Habibzadeh, Parham and Mofatteh, Mohammad and Ghavami, Saeid and Roozbeh, Jamshid, The potential effectiveness of acetazolamide in the prevention of acute kidney injury in COVID-19: A hypothesis (June 4, 2020). Parham Habibzadeh, Mohammad Mofatteh, Saeid Ghavami, Jamshid Roozbeh, The potential effectiveness of acetazolamide in the prevention of acute kidney injury in COVID-19: A hypothesis, European Journal of Pharmacology, Volume 888, 2020, 173487, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2020.17, Available at SSRN: https://ssrn.com/abstract=3619438 or http://dx.doi.org/10.2139/ssrn.3619438

Parham Habibzadeh

Shiraz University of Medical Sciences ( email )

Zand Ave
Shiraz, Fars
Iran

Mohammad Mofatteh

University of Oxford ( email )

Turl Street
Oxford, Oxfordshire OX1 3DR
United Kingdom
01865275532 (Phone)
OX1 4JD (Fax)

HOME PAGE: http://https://lincoln.ox.ac.uk/people/dr-mohammad-mofatteh

Saeid Ghavami

University of Manitoba ( email )

501 F.A. Bldg
Winnipeg R3T 5V4, Manitoba R3T 5V5
Canada

Jamshid Roozbeh (Contact Author)

Shiraz University of Medical Sciences ( email )

Zand Ave
Shiraz, Fars
Iran

Do you have a job opening that you would like to promote on SSRN?

Paper statistics

Downloads
222
Abstract Views
2,065
rank
178,852
PlumX Metrics