UV-C Irradiation Is Highly Effective in Inactivating and Inhibiting SARS-CoV-2 Replication

9 Pages Posted: 16 Jun 2020

See all articles by Andrea Bianco

Andrea Bianco

Italian National Institute for Astrophysics (INAF) – Brera Astronomical Observatory

Mara Biasin

Universita di Milano - Department of Biomedical and Clinical Sciences L. Sacco

Giovanni Pareschi

Italian National Institute for Astrophysics (INAF) – Brera Astronomical Observatory

Adalberto Cavalleri

Fondazione IRCCS Istituto Nazionale dei Tumori

Claudia Cavatorta

Fondazione IRCCS Istituto Nazionale dei Tumori

Fabio Fenizia

Universita di Milano

Paola Galli

Istituto Nazionale di Astrofisica (INAF) - Milano

Luigi Lessio

Istituto Nazionale di Astrofisica (INAF) - Milano

Manuela Lualdi

Fondazione IRCCS Istituto Nazionale dei Tumori

Edoardo Redaelli

Istituto Nazionale di Astrofisica (INAF) - Milano

Irma Saulle

Universita di Milano

Daria Trabattoni

Universita di Milano - Department of Biomedical and Clinical Sciences L. Sacco

Alessio Zanutta

Istituto Nazionale di Astrofisica (INAF) - Milano

Mario Clerici

University of Milano - Department of Pathophysiology and Transplantation

Date Written: June 5, 2020

Abstract

The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). Both virus inactivation and replication inhibition were investigated as a function of these parameters.At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm2 was sufficient to achieve a 3-log inactivation,and complete inhibition of all viral concentrations was observed with 16.9 mJ/cm2. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.

Note: Funding: This research was partially supported by a grant from Falk Renewables and it has been carried out in the context of the activities promoted by the Italian Government and in particular, by the Ministries of Health and of University and Research, against the COVID-19 pandemic.

Declaration of Interest: None to declare

Keywords: COVID19, SARS-COV-2, UV-C light, virus inactivation, virus replication inhibition, UC disinfection

Suggested Citation

Bianco, Andrea and Biasin, Mara and Pareschi, Giovanni and Cavalleri, Adalberto and Cavatorta, Claudia and Fenizia, Fabio and Galli, Paola and Lessio, Luigi and Lualdi, Manuela and Redaelli, Edoardo and Saulle, Irma and Trabattoni, Daria and Zanutta, Alessio and Clerici, Mario, UV-C Irradiation Is Highly Effective in Inactivating and Inhibiting SARS-CoV-2 Replication (June 5, 2020). Available at SSRN: https://ssrn.com/abstract=3620830 or http://dx.doi.org/10.2139/ssrn.3620830

Andrea Bianco (Contact Author)

Italian National Institute for Astrophysics (INAF) – Brera Astronomical Observatory ( email )

Via e. Bianchi 46
Merate, Lc 23805
Italy

Mara Biasin

Universita di Milano - Department of Biomedical and Clinical Sciences L. Sacco ( email )

via Golgi 19
Milano, I-20133
Italy

Giovanni Pareschi

Italian National Institute for Astrophysics (INAF) – Brera Astronomical Observatory ( email )

Via e. Bianchi 46
Merate, Lc 23805
Italy

Adalberto Cavalleri

Fondazione IRCCS Istituto Nazionale dei Tumori ( email )

Via Giacomo Venezian, 1
Milano MI, 20133
Italy

Claudia Cavatorta

Fondazione IRCCS Istituto Nazionale dei Tumori ( email )

Via Giacomo Venezian, 1
Milano MI, 20133
Italy

Fabio Fenizia

Universita di Milano ( email )

via Golgi 19
Milano, I-20133
Italy

Paola Galli

Istituto Nazionale di Astrofisica (INAF) - Milano ( email )

Via e. Bianchi 46
Merate, Lc 23805
Italy

Luigi Lessio

Istituto Nazionale di Astrofisica (INAF) - Milano ( email )

Via e. Bianchi 46
Merate, Lc 23805
Italy

Manuela Lualdi

Fondazione IRCCS Istituto Nazionale dei Tumori ( email )

Via Giacomo Venezian, 1
Milano MI, 20133
Italy

Edoardo Redaelli

Istituto Nazionale di Astrofisica (INAF) - Milano ( email )

Via e. Bianchi 46
Merate, Lc 23805
Italy

Irma Saulle

Universita di Milano ( email )

via Golgi 19
Milano, I-20133
Italy

Daria Trabattoni

Universita di Milano - Department of Biomedical and Clinical Sciences L. Sacco ( email )

via Golgi 19
Milano, I-20133
Italy

Alessio Zanutta

Istituto Nazionale di Astrofisica (INAF) - Milano ( email )

Via e. Bianchi 46
Merate, Lc 23805
Italy

Mario Clerici

University of Milano - Department of Pathophysiology and Transplantation ( email )

via Golgi 19
Milano, I-20133
Italy

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