Screening of Kabasura Kudineer Chooranam Against COVID-19 Through Targeting of Main Protease and RNA-Dependent RNA Polymerase of SARS-CoV-2 by Molecular Docking Studies

38 Pages Posted: 17 Jun 2020

See all articles by Gopalasatheeskumar K

Gopalasatheeskumar K

Annamalai University - Department of Pharmacy

Karthikeyen Lakshmanan

Madras Medical College, College of Pharmacy, Department of Pharmaceutical Chemistry

Anguraj Moulishankar

Madras Medical College, College of Pharmacy, Department of Pharmaceutical Chemistry

Jerad Suresh

Madras Medical College - Department of Pharmaceutical Chemistry

Kalaichelvan VK

Annamalai University - Department of Pharmacy

Kumudhaveni B

Madras Medical College - Department of Pharmaceutical Chemistry

Date Written: June 12, 2020

Abstract

Background: COVID-19 is the infectious pandemic disease caused by the novel coronavirus. The COVID-19 is spread globally in a short span of time. It was first identified in Wuhan, China in December 2019. According to the WHO reports as on 14th April 20, 2020,as affected about 17,73,084 people and recorded 1,11,652 deaths globally. The Indian Council of Medical Research (ICMR) has recommended chemoprophylaxis with Hydroxychloroquine for the management of COVID-19. The Department of AYUSH which promotes Siddha and other Indian system of Medicine recommends the use of formulation like Nilavembu Kudineer and Kaba Sura Kudineer Chooranam (KSKC). The current work seeks to provide the scientific bases for the use of KSKC.
Method: The present work seeks to provide the evidence for the action of 74 different constituents of the KSKC formulation acting on two critical targets. That is main protease and SARS-Cov-2 RNA-dependent RNA polymerase target through molecular docking experiments. The molecular docking was done by using AutoDock Tools 1.5.6.

Result: Of the 74 compounds 50 compounds yielded docking results against COVID-19 main protease while 42 compounds yielded against SARS-cov2 RNA-dependent RNA polymerase.

Conclusion: This research has concluded that the KSKC has the lead molecules that inhibits COVID-19’s target of main protease of COVID-19 and SARSCov-2 RNA-dependent RNA polymerase.

Note: Funding: None.

Conflict of Interest: None.

Keywords: SARS-CoV-2, AYUSH, Computational model, AutoDock, In silico, Siddha

Suggested Citation

K, Gopalasatheeskumar and Lakshmanan, Karthikeyen and Moulishankar, Anguraj and Suresh, Jerad and VK, Kalaichelvan and B, Kumudhaveni, Screening of Kabasura Kudineer Chooranam Against COVID-19 Through Targeting of Main Protease and RNA-Dependent RNA Polymerase of SARS-CoV-2 by Molecular Docking Studies (June 12, 2020). Available at SSRN: https://ssrn.com/abstract=3625653 or http://dx.doi.org/10.2139/ssrn.3625653

Gopalasatheeskumar K (Contact Author)

Annamalai University - Department of Pharmacy ( email )

Annamalainagar
Chidambaram, Tamil Nadu 608002
India
9790035017 (Phone)

Karthikeyen Lakshmanan

Madras Medical College, College of Pharmacy, Department of Pharmaceutical Chemistry ( email )

India

Anguraj Moulishankar

Madras Medical College, College of Pharmacy, Department of Pharmaceutical Chemistry ( email )

India

Jerad Suresh

Madras Medical College - Department of Pharmaceutical Chemistry ( email )

India

Kalaichelvan VK

Annamalai University - Department of Pharmacy ( email )

Annamalainagar
Chidambaram, Tamil Nadu 608002
India

Kumudhaveni B

Madras Medical College - Department of Pharmaceutical Chemistry ( email )

India

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