Epigallocatechin-3-Gallate/Nanohydroxyapatite Platform Delivery Approach to Adhesive-Dentin Interface

36 Pages Posted: 13 Jul 2020

See all articles by Jian Yu

Jian Yu

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University

Zhongni Zhang

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University

Rui Guo

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University

Wenan Peng

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University

Hongye Yang

Wuhan University - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST)

Cui Huang

Wuhan University - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST)

Abstract

Interface science is an intrinsic component of dental bonding. Current adhesive techniques allow clinicians to bond resin composites to dentin for the restoration of a defected tooth. However, a vulnerable adhesive-dentin interface remains clinically challenging by far resulting in frequent replacement of the restorations. The inappropriate management of exposed dentin plays a major role in jeopardizing the stability of the adhesive-dentin interface, leading to subsequent restorative failure. To overcome this problem, this paper highlights epigallocatechin-3-gallate/nanohydroxyapatite (EGCG/nHAp) platform (mesoporous silica-based) delivery approach to the adhesive-dentin interface and investigates its effectiveness on dentin bonding. Microtensile bond strength, interfacial nanoleakage, in situ zymography, and Streptococcus mutans biofilm formation were assessed. Results revealed that applying the EGCG/nHAp delivery platform on exposed dentin could preserve the dentin bond strength and reduce interfacial nanoleakage after collagenase ageing; moreover, it could inactivate the activity of matrix metalloproteinase within the hybrid layer and inhibit the adhesion and biofilm formation of Streptococcus mutans. The proposed approach demonstrates great potential for stabilizing the adhesive-dentin interface, which may aid in achieving a durable dentin bonding efficiency and preventing secondary caries progression, thereby indicating a promising strategy to prolong the service life of dental restorations.

Suggested Citation

Yu, Jian and Zhang, Zhongni and Guo, Rui and Peng, Wenan and Yang, Hongye and Huang, Cui, Epigallocatechin-3-Gallate/Nanohydroxyapatite Platform Delivery Approach to Adhesive-Dentin Interface. Available at SSRN: https://ssrn.com/abstract=3640712 or http://dx.doi.org/10.2139/ssrn.3640712

Jian Yu

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University

Zhongni Zhang

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University

Rui Guo

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University

Wenan Peng

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University

Hongye Yang (Contact Author)

Wuhan University - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) ( email )

Wuhan, 430071
China

Cui Huang

Wuhan University - The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) ( email )

Wuhan, 430071
China

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