Vitamin D, Zinc and Glutamine: Synergistic Action with OncoTherad Immunomodulator in Interferon Signaling and COVID-19
19 Pages Posted: 29 Jul 2020
Date Written: July 13, 2020
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in December 2019 in Wuhan, China, and has continued to spread rapidly in numerous countries while the search for effective therapeutic options persists. Coronaviruses, including SARS-CoV-2, are known to suppress and evade the host organism's antiviral responses mediated by interferon (IFN), a family of cytokines that plays an important role in antiviral defenses associated with innate immunity and has been used therapeutically for chronic viral diseases and cancer. On the other hand, OncoTherad, a safe and effective immunotherapeutic agent in the treatment of non-muscle invasive bladder cancer (NMIBC), increases IFN signaling and was shown to be a promising therapeutic approach for COVID-19 in a case report that described the rapid recovery of a 78-year-old NMIBC patient with comorbidities. This review aims to explore the possible synergistic action of OncoTherad with vitamin D, zinc and glutamine, nutrients that have been proven to facilitate immune responses mediated by IFN signaling, as well as the potential of this combination in modulating immune function in the treatment of COVID-19.
Note: Conflict of Interest: The authors declare no competing interests.
Funding: This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) [313152/2018-7] to W.J.F.
Keywords: COVID-19, SARS-CoV-2, Interferon, Immunity, zinc, glutamine, vitamin D, OncoTherad
JEL Classification: I1
Suggested Citation: Suggested Citation