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Closed-Loop Neurofeedback of Alpha Synchrony During Goal-Directed Attention

33 Pages Posted: 12 Aug 2020 Publication Status: Review Complete

See all articles by Jyoti Mishra

Jyoti Mishra

University of California, San Diego (UCSD) - Department of Psychiatry

Mira Lowenstein

University of California, San Francisco (UCSF) - Department of Neurology

Richard Campusano

University of California, San Francisco (UCSF) - Department of Neurology

Juan Diaz-Delgado

University of California, San Diego (UCSD) - Department of Psychiatry

Jacqueline Ayyoub

University of California, San Francisco (UCSF) - Department of Neurology

Rajat Jain

University of California, San Francisco (UCSF) - Department of Neurology

Adam Gazzaley

University of California, San Francisco (UCSF) - Department of Neurology

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Abstract

Alpha oscillations in sensory cortex, under frontal control, desynchronize during attentive preparation. Here, in a selective attention study with simultaneous EEG, we first demonstrate that diminished anticipatory alpha synchrony between the mid-frontal region of the dorsal attention network and ventral visual sensory cortex (frontal-sensory synchrony (FSS)) significantly correlates with greater task performance. Then, in a double-blind, randomized controlled study in healthy adults, we implement closed-loop neurofeedback of the anticipatory alpha FSS signal over ten days of training, showing significant trial-by-trial modulation of the anticipatory alpha FSS measure during training, concomitant plasticity of stimulus-evoked alpha/theta responses, as well as transfer of benefits to response time improvements on a standard test of sustained attention. In a third study, we replicate closed-loop neurofeedback training in children with ADHD, showing trial-by-trial modulation of the anticipatory alpha FSS signal, and significant improvement of sustained attention response times. These findings demonstrate utility of cognitive-task-integrated neurofeedback.

Keywords: attention, cognitive neurofeedback, closed-loop, brain computer interface, synchrony, dorsal attention network, Attention Deficit Hyperactivity Disorder, anticipation, alpha suppression, neuroplasticity

Suggested Citation

Mishra, Jyoti and Lowenstein, Mira and Campusano, Richard and Diaz-Delgado, Juan and Ayyoub, Jacqueline and Jain, Rajat and Gazzaley, Adam, Closed-Loop Neurofeedback of Alpha Synchrony During Goal-Directed Attention. Available at SSRN: https://ssrn.com/abstract=3652329 or http://dx.doi.org/10.2139/ssrn.3652329
This version of the paper has not been formally peer reviewed.

Jyoti Mishra (Contact Author)

University of California, San Diego (UCSD) - Department of Psychiatry ( email )

La Jolla, CA 92161
United States

Mira Lowenstein

University of California, San Francisco (UCSF) - Department of Neurology ( email )

San Francisco, CA 94143
United States

Richard Campusano

University of California, San Francisco (UCSF) - Department of Neurology ( email )

San Francisco, CA 94143
United States

Juan Diaz-Delgado

University of California, San Diego (UCSD) - Department of Psychiatry ( email )

La Jolla, CA 92161
United States

Jacqueline Ayyoub

University of California, San Francisco (UCSF) - Department of Neurology ( email )

San Francisco, CA 94143
United States

Rajat Jain

University of California, San Francisco (UCSF) - Department of Neurology ( email )

San Francisco, CA 94143
United States

Adam Gazzaley

University of California, San Francisco (UCSF) - Department of Neurology

San Francisco, CA 94143
United States

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