Metal Complexation of Deferasirox Derivatives: A Solid State and Equilibrium Study

POLYH-D-20-00809

26 Pages Posted: 23 Jul 2020

See all articles by Peter Buglyo

Peter Buglyo

University of Debrecen

Imre Nagy

affiliation not provided to SSRN

Gergő Tamás Ferenczik

affiliation not provided to SSRN

Linda Bíró

affiliation not provided to SSRN

Etelka Farkas

affiliation not provided to SSRN

Attila Cs. Bényei

University of Debrecen

Abstract

Complexation of deferasirox (4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid, H 3 L B ) and its decarboxylated derivative (H 2 L A ) with Ru(III), Os(IV), Co(III) and Ga(III) was studied. These complexes are expected to show anticancer potential. Formation of 1:2 octahedral complexes via a (O,N,O) tridentate coordination of the ligands was detected to yield K 3 [Ru(L B ) 2 ], K[Co(L A ) 2 ], K 3 [Co(L B ) 2 ] and (guanidinium)Na 2 [Ga(L B ) 2 ], respectively. The molecular structure by single crystal X-ray diffraction also confirmed the octahedral geometry for K[Co(L A ) 2 ].2Pr i OH. Unprecedented formation of K 2 [Os VI L B (O) 2 (OH)] having a tridentate (O,N,O) coordinating ligand, two oxo groups and an a hydroxide ion in the coordination sphere of the metal ion of  +6 oxidation state was also found. Simple synthesis and solid state structure of the novel disulfonated derivatives of L B , and L A , (L D and L C , respectively, with excellent water solubility) is also presented. Interaction of Ga(III) with H 5 L D and H 4 L C resulted in the formation of 1:1 and 1:2 complexes with different protonation degree in aqueous solution among them [Ga(L D ) 2 ] 7– and [Ga(L C ) 2 ] 5– being the major species under physiologically relevant conditions.

Suggested Citation

Buglyo, Peter and Nagy, Imre and Ferenczik, Gergő Tamás and Bíró, Linda and Farkas, Etelka and Bényei, Attila Cs., Metal Complexation of Deferasirox Derivatives: A Solid State and Equilibrium Study. POLYH-D-20-00809, Available at SSRN: https://ssrn.com/abstract=3656989

Peter Buglyo (Contact Author)

University of Debrecen

Imre Nagy

affiliation not provided to SSRN

Gergő Tamás Ferenczik

affiliation not provided to SSRN

Linda Bíró

affiliation not provided to SSRN

Etelka Farkas

affiliation not provided to SSRN

Attila Cs. Bényei

University of Debrecen

Böszörményi u. 138
H-4032 Debrecen, 4032
Hungary

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