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The Roborovski Dwarf Hamster – A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection

33 Pages Posted: 17 Aug 2020 Publication Status: Review Complete

See all articles by Jakob Trimpert

Jakob Trimpert

Free University of Berlin (FUB) - Institut für Virologie

Daria Vladimirova

Free University of Berlin (FUB) - Institut für Virologie

Kristina Dietert

Free University of Berlin (FUB) - Institut für Tierpathologie

Azza Abdelgawad

Free University of Berlin (FUB) - Institut für Virologie

Dusan Kunec

Free University of Berlin (FUB) - Institut für Virologie

Simon Dökel

Free University of Berlin (FUB) - Institut für Tierpathologie

Achim Gruber

Free University of Berlin (FUB) - Institut für Tierpathologie

Luca Bertzbach

Free University of Berlin (FUB) - Institut für Virologie

Nikolaus Osterrieder

Free University of Berlin (FUB) - Institut für Virologie

More...

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 has precipitated an unprecedented and yet unresolved crisis worldwide. Different mammals are susceptible to SARS-CoV-2; however, no species examined so far develops robust clinical disease that mirrors severe human cases or allows testing of vaccines and drugs under conditions of severe disease. Here, we compare the susceptibility of three dwarf hamster species (Phodopus spp.) to SARS-CoV-2 and introduce the Roborovski dwarf hamster (P. roborovskii) as a highly susceptible COVID-19 model with consistent and fulminant clinical signs. Particularly, this species shows SARS-CoV-2-induced severe acute diffuse alveolar damage and hyaline microthrombi in the lungs, changes described in patients who succumbed to the infection, but so far not reproduced in any experimentally infected animal. We therefore propose the Roborovski dwarf hamster as an ideal model to examine the efficacy and safety of live attenuated vaccine candidates and novel therapeutics, particularly for their use in highly susceptible individuals.

Keywords: coronavirus, animal model, COVID-19, pneumonia, histopathology, thrombosis, Campbell's dwarf hamster (Phodopus campbelli), Djungarian hamster (Phodopus sungorus), Roborovski dwarf hamster (Phodopus roborovskii)

Suggested Citation

Trimpert, Jakob and Vladimirova, Daria and Dietert, Kristina and Abdelgawad, Azza and Kunec, Dusan and Dökel, Simon and Gruber, Achim and Bertzbach, Luca and Osterrieder, Nikolaus, The Roborovski Dwarf Hamster – A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection. Available at SSRN: https://ssrn.com/abstract=3659394 or http://dx.doi.org/10.2139/ssrn.3659394
This version of the paper has not been formally peer reviewed.

Jakob Trimpert (Contact Author)

Free University of Berlin (FUB) - Institut für Virologie ( email )

Germany

Daria Vladimirova

Free University of Berlin (FUB) - Institut für Virologie ( email )

Germany

Kristina Dietert

Free University of Berlin (FUB) - Institut für Tierpathologie ( email )

Van't-Hoff-Str. 8
Berlin, Berlin 14195
Germany

Azza Abdelgawad

Free University of Berlin (FUB) - Institut für Virologie ( email )

Germany

Dusan Kunec

Free University of Berlin (FUB) - Institut für Virologie ( email )

Germany

Simon Dökel

Free University of Berlin (FUB) - Institut für Tierpathologie ( email )

Van't-Hoff-Str. 8
Berlin, Berlin 14195
Germany

Achim Gruber

Free University of Berlin (FUB) - Institut für Tierpathologie ( email )

Van't-Hoff-Str. 8
Berlin, Berlin 14195
Germany

Luca Bertzbach

Free University of Berlin (FUB) - Institut für Virologie ( email )

Germany

Nikolaus Osterrieder

Free University of Berlin (FUB) - Institut für Virologie ( email )

Germany

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