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Archaeogenomic Distinctiveness of the Isthmo-Colombian Area

73 Pages Posted: 27 Aug 2020 Publication Status: Review Complete

See all articles by Marco Rosario Capodiferro

Marco Rosario Capodiferro

University of Pavia - Department of Biology and Biotechnology

Alessandro Raveane

University of Pavia - Department of Biology and Biotechnology

Nicola Rambaldi Migliore

University of Pavia - Department of Biology and Biotechnology

Giulia Colombo

University of Pavia - Department of Biology and Biotechnology

Linda Ongaro

University of Tartu - Estonian Biocentre

Javier Rivera

Universidad del Norte - Department of History and Social Sciences

Tomas Mendizábal

Patronato Panamá Viejo

Iosvany Hernández-Mora

Universidad del Norte - Department of History and Social Sciences

Maribel Tribaldos

Gorgas Memorial Institute for Health Studies

Ugo Alessandro Perego

University of Pavia - Department of Biology and Biotechnology

Christiana Lyn Scheib

University of Tartu - Estonian Biocentre

Alessandra Modi

University of Florence - Department of Biology

Alberto Gòmez-Carballa

Universidade de Santiago de Compostela - Unidade de Xenética

Viola Grugni

University of Pavia - Department of Biology and Biotechnology

Gianluca Lombardo

University of Pavia - Department of Biology and Biotechnology

Garrett Hellenthal

University College London - Department of Genetics

Juan Miguel Pascale

Gorgas Memorial Institute for Health Studies

Gaetano Grieco

National Neurological Institute C. Mondino - Genomic and Post-Genomic Center

Cristina Cereda

IRCCS ‘C. Mondino’ National Institute of Neurology Foundation - Experimental Neurobiology Laboratory

Martina Lari

University of Florence - Department of Biology

David Caramelli

University of Florence - Department of Biology

Luca Pagani

University of Tartu - Estonian Biocentre; University of Padova

Mait Metspalu

University of Tartu - Estonian Biocentre

Corina Knipper

Curt Engelhorn Center Archaeometry (CEZA)

Anna Olivieri

University of Pavia - Department of Biology and Biotechnology

Antonio Salas

Universidade de Santiago de Compostela - Unidade de Xenética

Richard Cooke

Smithsonian Tropical Research Institute

Antonio Torroni

University of Pavia - Department of Biology and Biotechnology

Francesco Montinaro

University of Tartu - Estonian Biocentre

Jorge Motta

Gorgas Memorial Institute for Health Studies

Juan Guillermo Martín

Universidad del Norte - Department of History and Social Sciences

Ornella Semino

University of Pavia - Department of Biology and Biotechnology

Ripan Singh Malhi

University of Illinois at Urbana-Champaign - Department of Anthropology

Bethany Aram

University Pablo Olavide of Seville - Department of Geography

Alessandro Achilli

University of Pavia - Department of Biology and Biotechnology

More...

Abstract

The genomic histories of Indigenous groups in the Americas have been recently enriched by modern and ancient data, but the dataset on continental Central America is still meagre. Here, we report ten ancient pre-Hispanic (plus two early colonial) genomes and 84 genome-wide profiles from seven groups presently living in Panama, on the Isthmian land-bridge connecting North and South America. Our analysis reveals extensive sub-structure in the geographic area with pre-colonial Panamanians clustering separately. On a continental scale, the Isthmian populations are distinguished by a previously unknown Indigenous component in the Americas. This component derives from the admixture of different early Indigenous groups that originated from the same northern North American source in the late Pleistocene. The earlier population(s) moved further south, leaving differential footprints in South America, while another group remained restricted to the Isthmo-Colombian area, expanded locally during the early Holocene and left genomic traces up to now.

Keywords: Archaeogenomics, Ancient and Modern DNA, Indigenous Populations, Native Americans, Panama, Population Genetics

Suggested Citation

Capodiferro, Marco Rosario and Raveane, Alessandro and Rambaldi Migliore, Nicola and Colombo, Giulia and Ongaro, Linda and Rivera, Javier and Mendizábal, Tomas and Hernández-Mora, Iosvany and Tribaldos, Maribel and Perego, Ugo Alessandro and Scheib, Christiana Lyn and Modi, Alessandra and Gòmez-Carballa, Alberto and Grugni, Viola and Lombardo, Gianluca and Hellenthal, Garrett and Pascale, Juan Miguel and Grieco, Gaetano and Cereda, Cristina and Lari, Martina and Caramelli, David and Pagani, Luca and Metspalu, Mait and Knipper, Corina and Olivieri, Anna and Salas, Antonio and Cooke, Richard and Torroni, Antonio and Montinaro, Francesco and Motta, Jorge and Martín, Juan Guillermo and Semino, Ornella and Malhi, Ripan Singh and Aram, Bethany and Achilli, Alessandro, Archaeogenomic Distinctiveness of the Isthmo-Colombian Area. Available at SSRN: https://ssrn.com/abstract=3661949 or http://dx.doi.org/10.2139/ssrn.3661949
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Marco Rosario Capodiferro

University of Pavia - Department of Biology and Biotechnology ( email )

Corso Str. Nuova, 65, 27100
Pavia
Italy
+390382985553 (Phone)

Alessandro Raveane

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Nicola Rambaldi Migliore

University of Pavia - Department of Biology and Biotechnology ( email )

Corso Str. Nuova, 65, 27100
Pavia
Italy

Giulia Colombo

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Linda Ongaro

University of Tartu - Estonian Biocentre ( email )

Tartu
Estonia

Javier Rivera

Universidad del Norte - Department of History and Social Sciences

Km5 Via Puerto Colombia
Carrera 58 # 82-84 Apt 6B
Barranquilla, Atlantico
Colombia

Tomas Mendizábal

Patronato Panamá Viejo ( email )

Iosvany Hernández-Mora

Universidad del Norte - Department of History and Social Sciences ( email )

Km5 Via Puerto Colombia
Carrera 58 # 82-84 Apt 6B
Barranquilla, Atlantico
Colombia

Maribel Tribaldos

Gorgas Memorial Institute for Health Studies ( email )

Ugo Alessandro Perego

University of Pavia - Department of Biology and Biotechnology ( email )

Corso Str. Nuova, 65, 27100
Pavia
Italy

Christiana Lyn Scheib

University of Tartu - Estonian Biocentre

Tartu
Estonia

Alessandra Modi

University of Florence - Department of Biology

Piazza di San Marco, 4
Florence, 50121
Italy

Alberto Gòmez-Carballa

Universidade de Santiago de Compostela - Unidade de Xenética ( email )

Complejo Docente - Campus Universitario de Lugo
Lugo, A Coruña 15704
Spain

Viola Grugni

University of Pavia - Department of Biology and Biotechnology ( email )

Corso Str. Nuova, 65, 27100
Pavia
Italy

Gianluca Lombardo

University of Pavia - Department of Biology and Biotechnology ( email )

Corso Str. Nuova, 65, 27100
Pavia
Italy

Garrett Hellenthal

University College London - Department of Genetics

Gower Street
London, WC1E 6BT
United Kingdom

Juan Miguel Pascale

Gorgas Memorial Institute for Health Studies ( email )

Gaetano Grieco

National Neurological Institute C. Mondino - Genomic and Post-Genomic Center ( email )

Mondino 2
Pavia, 27100
Italy

Cristina Cereda

IRCCS ‘C. Mondino’ National Institute of Neurology Foundation - Experimental Neurobiology Laboratory

Mondino 2
Pavia, 27100
Italy

Martina Lari

University of Florence - Department of Biology ( email )

Piazza di San Marco, 4
Florence, 50121
Italy

David Caramelli

University of Florence - Department of Biology ( email )

Piazza di San Marco, 4
Florence, 50121
Italy

Luca Pagani

University of Tartu - Estonian Biocentre

Tartu
Estonia

University of Padova

Via 8 Febbraio
Padova, Vicenza 2-35122
Italy

Mait Metspalu

University of Tartu - Estonian Biocentre

Tartu
Estonia

Corina Knipper

Curt Engelhorn Center Archaeometry (CEZA) ( email )

Anna Olivieri

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Antonio Salas

Universidade de Santiago de Compostela - Unidade de Xenética

Complejo Docente - Campus Universitario de Lugo
Lugo, A Coruña 15704
Spain

Richard Cooke

Smithsonian Tropical Research Institute ( email )

Antonio Torroni

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Francesco Montinaro

University of Tartu - Estonian Biocentre

Tartu
Estonia

Jorge Motta

Gorgas Memorial Institute for Health Studies

Juan Guillermo Martín

Universidad del Norte - Department of History and Social Sciences ( email )

Km5 Via Puerto Colombia
Carrera 58 # 82-84 Apt 6B
Barranquilla, Atlantico
Colombia

Ornella Semino

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Ripan Singh Malhi

University of Illinois at Urbana-Champaign - Department of Anthropology ( email )

601 E John St
Champaign, IL 61820
United States

Bethany Aram

University Pablo Olavide of Seville - Department of Geography ( email )

Seville
Spain

Alessandro Achilli (Contact Author)

University of Pavia - Department of Biology and Biotechnology ( email )

Corso Str. Nuova, 65, 27100
Pavia
Italy

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