A Lindqvist-Type [W 6O 19] 2‒ Organic-Inorganic Compound: Synthesis, Characterization, Antibacterial Activity and Preliminary Studies on the Mechanism of Action

17 Pages Posted: 1 Aug 2020

See all articles by Meng Zhao

Meng Zhao

Henan University

Xiyu Zhu

Henan University

Jing Liu

Henan University

Lihua Ma

affiliation not provided to SSRN

Xiaoyuan Guo

affiliation not provided to SSRN

Mingxue Li

Henan University

Abstract

In this paper, a new organic-inorganic hybrid compound [Co(L)2]2 [W6O19](1) (HL = 2-acetylpyridine thiosemicarbazone) was prepared and characterized. The compound exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus, 0.06 µg/mL) and Escherichia coli (E. coli, 0.24 µg/mL), respectively. Furthermore, the potential mechanism of 1 was studied in detail. The potential causes of bacteria death were cell wall/membrane disruption, inhibition of intracellular respiratory chain dehydrogenases activity (RCD), breach of reactive oxygen species (ROS) and glutathione (GSH).

Keywords: Polyoxometalate, Thiosemicarbazone, Bioactivity, Mechanism of action

Suggested Citation

Zhao, Meng and Zhu, Xiyu and Liu, Jing and Ma, Lihua and Guo, Xiaoyuan and Li, Mingxue, A Lindqvist-Type [W 6O 19] 2‒ Organic-Inorganic Compound: Synthesis, Characterization, Antibacterial Activity and Preliminary Studies on the Mechanism of Action. Available at SSRN: https://ssrn.com/abstract=3662170

Meng Zhao

Henan University

85 Minglun St. Shunhe
Kaifeng, Henan 475001
China

Xiyu Zhu

Henan University

85 Minglun St. Shunhe
Kaifeng, Henan 475001
China

Jing Liu

Henan University

85 Minglun St. Shunhe
Kaifeng, Henan 475001
China

Lihua Ma

affiliation not provided to SSRN

Xiaoyuan Guo

affiliation not provided to SSRN

No Address Available

Mingxue Li (Contact Author)

Henan University ( email )

85 Minglun St. Shunhe
Kaifeng, Henan 475001
China

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